Literature DB >> 6402992

Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture.

J A Salmon, G A Higgs, J R Vane, L Bitensky, J Chayen, B Henderson, B Cashman.   

Abstract

Specimens of human rheumatoid and nonrheumatoid synovial lining were maintained in nonproliferative organ culture for 20 hours. The culture fluids were then assayed for prostaglandin E(2) (PGE(2)), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) by specific radioimmunoassay. The presence of each of these substances was confirmed by gas chromatography and mass spectrometry. Rheumatoid tissue produced significantly more of each cyclo-oxygenase product than nonrheumatoid tissue.

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Year:  1983        PMID： 6402992      PMCID： PMC1001056          DOI： 10.1136/ard.42.1.36

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  11 in total

Review 1.  Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

Authors:  S Moncada; J R Vane
Journal:  Pharmacol Rev       Date:  1978-09       Impact factor: 25.468

2.  Is prostacyclin in the major pro-inflammatory prostanoid in joint fluid?

Authors:  M J Brodie; C N Hensby; A Parke; D Gordon
Journal:  Life Sci       Date:  1980-08-18       Impact factor: 5.037

3.  The maintenance of human synovial tissue in vitro.

Authors:  L W Poulter; L Bitensky; B Cashman; J Chayen
Journal:  Virchows Arch B Cell Pathol       Date:  1970

4.  Levels of prostaglandins F2 alpha and E2 and thromboxane B2 in joint fluid in rheumatoid arthritis.

Authors:  L E Trang; E Granström; O Lövgren
Journal:  Scand J Rheumatol       Date:  1977       Impact factor: 3.641

5.  Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine.

Authors:  D R Robinson; H Smith; M B McGuire; L Levine
Journal:  Prostaglandins       Date:  1975-07

6.  Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.

Authors:  D Crook; A J Collins; P A Bacon; R Chan
Journal:  Ann Rheum Dis       Date:  1976-08       Impact factor: 19.103

7.  PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia.

Authors:  F Blotman; J Chaintreuil; P Poubelle; O Flandre; A Crastes de Paulet; L Simon
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

8.  A radioimmunoassay for 6-keto-prostaglandin F1alpha.

Authors:  J A Salmon
Journal:  Prostaglandins       Date:  1978-03

9.  Prostaglandin production in arthritis.

Authors:  R A Sturge; D B Yates; D Gordon; M Franco; W Paul; A Bray; J Morley
Journal:  Ann Rheum Dis       Date:  1978-08       Impact factor: 19.103

10.  Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes.

Authors:  E A Kitchen; J R Boot; W Dawson
Journal:  Prostaglandins       Date:  1978-08
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  17 in total

Review 1.  Synovial fluid phospholipase A2s and inflammation.

Authors:  H Gonzalez-Buritica; M A Khamashita; G R Hughes
Journal:  Ann Rheum Dis       Date:  1989-04       Impact factor: 19.103

2.  Synthesis of eicosanoids by tissues of the synovial joint during the development of chronic erosive synovitis.

Authors:  B Henderson; G A Higgs; S Moncada; J A Salmon
Journal:  Agents Actions       Date:  1986-01

3.  Effects of diclofenac, indomethacin, tolfenamic acid and hydrocortisone on prostanoid production in healthy and rheumatic synovial cells.

Authors:  E Moilanen
Journal:  Agents Actions       Date:  1989-03

Review 4.  The contribution made by cytochemistry to the study of the metabolism of the normal and rheumatoid synovial lining cell (synoviocyte).

Authors:  B Henderson
Journal:  Histochem J       Date:  1982-07

5.  Eicosanoid production in rheumatoid synovitis.

Authors:  E Moilanen; J Alanko; M Nissilä; M Hämäläinen; H Isomäki; H Vapaatalo
Journal:  Agents Actions       Date:  1989-11

6.  Peripheral blood mononuclear cells stimulate prostacyclin levels of human synovial fibroblast-like cells.

Authors:  J A Hamilton; B J Clarris; J R Fraser; M C Niall
Journal:  Rheumatol Int       Date:  1985       Impact factor: 2.631

7.  Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture.

Authors:  I Knott; M Dieu; M Burton; V Lecomte; J Remacle; M Raes
Journal:  Agents Actions       Date:  1993-07

8.  Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits.

Authors:  K R Ingram; A K T Wann; R M Wingate; P J Coleman; N McHale; J R Levick
Journal:  J Physiol       Date:  2009-07-21       Impact factor: 5.182

9.  Differences in prostanoid production between healthy and rheumatic synovia in vitro.

Authors:  E Moilanen; E Seppälä; M Nissilä; H Vapaatalo
Journal:  Agents Actions       Date:  1987-02

10.  Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.

Authors:  E Seppälä; M Nissilä; H Isomäki; P Nuotio; E Nykänen; O Laitinen; H Vapaatalo
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980
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