Literature DB >> 663275

A radioimmunoassay for 6-keto-prostaglandin F1alpha.

J A Salmon.   

Abstract

A radioimmunoassay for 6-keto-prostaglandin F1alpha has been developed. The assay is accurate and sensitive but since the antiserum cross-reacts 5-10% with prostaglandins (PGs) of the E and F series, solvent extraction and thin layer chromatography are required for absolute specificity. The assay has been validated by comparison with a radiochemical assay and by the use of an inhibitor of 6-keto PGF1alpha formation, 15-hydroperoxy arachidonic acid. 6-Keto PGF1alpha was found to have a low cross reaction with antisera directed against PGE2, PGF2alpha and thromboxane B2.

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Year:  1978        PMID： 663275     DOI： 10.1016/0090-6980(78)90122-3

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  72 in total

1.  Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Authors:  D L Simmons; R M Botting; P M Robertson; M L Madsen; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

2.  Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis.

Authors:  Caroline B Appleyard; Adrian Alvarez; William H Percy
Journal:  Dig Dis Sci       Date:  2002-09       Impact factor: 3.199

3.  Free radicals in myocardial injury: experimental and clinical studies.

Authors:  N K Ganguly; K Nalini; S Wahi; V Dhawan; S Meenakshi; R N Chakravarti
Journal:  Mol Cell Biochem       Date:  1992-04       Impact factor: 3.396

4.  Inflammatory effects of Salmonella typhimurium porins.

Authors:  F Galdiero; M A Tufano; M Galdiero; S Masiello; M Di Rosa
Journal:  Infect Immun       Date:  1990-10       Impact factor: 3.441

5.  Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis.

Authors:  E R Pettipher; B Henderson; J C Edwards; G A Higgs
Journal:  Ann Rheum Dis       Date:  1989-08       Impact factor: 19.103

6.  Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.

Authors:  A G Stewart; W A Phillips
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

7.  Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit.

Authors:  E R Pettipher; B Henderson; S Moncada; G A Higgs
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

8.  Effect of dipyridamole on the formation of 6-oxo-prostaglandin F1 alpha by the rat isolated aorta and ram seminal vesicle microsomes.

Authors:  H Bult; A G Herman; V J Van de Velde
Journal:  Br J Pharmacol       Date:  1982-07       Impact factor: 8.739

9.  COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.

Authors:  N V Chandrasekharan; Hu Dai; K Lamar Turepu Roos; Nathan K Evanson; Joshua Tomsik; Terry S Elton; Daniel L Simmons
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-19       Impact factor: 11.205

10.  Alkaline buffers release EDRF from bovine cultured aortic endothelial cells.

Authors:  J A Mitchell; G de Nucci; T D Warner; J R Vane
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739
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