Literature DB >> 8304239

Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture.

I Knott1, M Dieu, M Burton, V Lecomte, J Remacle, M Raes.   

Abstract

The effects of interleukin-1 alpha and beta were tested on the [3H]-arachidonic acid release and the prostaglandin synthesis by human cultured synovial cells and chondrocytes. Both forms of interleukin-1 stimulated the arachidonic acid release but interleukin-1 beta was more potent than IL-1 alpha. Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1 alpha or beta: prostaglandin E2, F2 alpha and 6-keto-prostaglandin F1 alpha. Regarding the synthesis of these prostaglandins, IL-1 beta was again more potent than IL-1 alpha. A comparison between interleukin-1-stimulated synovial cells and chondrocytes revealed neither significant quantitative nor qualitative differences in both the arachidonic acid release and the prostaglandin synthesis.

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Year:  1993        PMID： 8304239     DOI： 10.1007/BF01998964

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  26 in total

1.  Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor.

Authors:  I K Campbell; D S Piccoli; J A Hamilton
Journal:  Biochim Biophys Acta       Date:  1990-03-09

2.  Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

Authors:  J M Dayer; S M Krane; R G Russell; D R Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

3.  Recombinant tumor necrosis factor and interleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism.

Authors:  R W Godfrey; W J Johnson; S T Hoffstein
Journal:  Biochem Biophys Res Commun       Date:  1987-01-15       Impact factor: 3.575

4.  Interleukin 1 receptors on rabbit articular chondrocytes: relationship between biological activity and receptor binding kinetics.

Authors:  J E Chin; R Horuk
Journal:  FASEB J       Date:  1990-03       Impact factor: 5.191

5.  Differences in prostanoid production between healthy and rheumatic synovia in vitro.

Authors:  E Moilanen; E Seppälä; M Nissilä; H Vapaatalo
Journal:  Agents Actions       Date:  1987-02

Review 6.  Interleukin-1 and osteoarthritis.

Authors:  J P Pujol; G Loyau
Journal:  Life Sci       Date:  1987-09-07       Impact factor: 5.037

7.  Interleukin-1 activates phospholipase A2 in human synovial cells.

Authors:  S C Gilman; J Chang; P R Zeigler; J Uhl; E Mochan
Journal:  Arthritis Rheum       Date:  1988-01

8.  Routine prostaglandin assay by GC-MS in multiwell tissue culture plates: application to human synoviocytes and chondrocytes.

Authors:  I Knott; M Raes; M Dieu; G Lenoir; M Burton; J Remacle
Journal:  Anal Biochem       Date:  1993-05-01       Impact factor: 3.365

9.  Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.

Authors:  I Gery; R K Gershon; B H Waksman
Journal:  J Exp Med       Date:  1972-07-01       Impact factor: 14.307

10.  Identification of a high-affinity receptor for native human interleukin 1 beta and interleukin 1 alpha on normal human lung fibroblasts.

Authors:  J Chin; P M Cameron; E Rupp; J A Schmidt
Journal:  J Exp Med       Date:  1987-01-01       Impact factor: 14.307
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  1 in total

1.  Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.

Authors:  Amy L McNulty; Nicole E Rothfusz; Holly A Leddy; Farshid Guilak
Journal:  J Orthop Res       Date:  2013-03-11       Impact factor: 3.494
  1 in total

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