Literature DB >> 6371547

Carcinogenic N-nitroso compounds and their environmental significance.

R Preussmann.   

Abstract

A short review is given on the potent and organ-specific carcinogenic effects of N-nitroso compounds. Like many other chemical carcinogens, nitrosamino compounds require activation in vivo via enzymatic alpha-hydroxylation to form alkylating agents as ultimate carcinogens. Since no epidemiological data in man are available, extrapolation of animal data to man are important as well as dose-response studies in risk evaluations. Important aspects of these problems are presented. Finally the environmental impact of N-nitroso compounds is summarized.

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Year:  1984        PMID： 6371547     DOI： 10.1007/bf00365976

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


  40 in total

1.  Estimate of the volatile nitrosamine content of Japanese food.

Authors:  T Maki; Y Tamura; Y Shimamura; Y Naoi
Journal:  Bull Environ Contam Toxicol       Date:  1980-08       Impact factor: 2.151

2.  Denitrosation of N-nitrosomorpholine by liver microsomes; possible role of cytochrome P-450.

Authors:  K E Appel; D Schrenk; M Schwarz; B Mahr; W Kunz
Journal:  Cancer Lett       Date:  1980-03       Impact factor: 8.679

3.  The mutagenicity of 45 nitrosamines in the Salmonella typhimurium.

Authors:  A W Andrews; W Lijinsky
Journal:  Teratog Carcinog Mutagen       Date:  1980

4.  Lethal exitus of a patient with N-nitrosodimethylamine poisoning, 2.5 years following the first ingestion and signs of intoxication.

Authors:  R D Fussgaenger; H Ditschuneit
Journal:  Oncology       Date:  1980       Impact factor: 2.935

5.  Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine.

Authors:  S S Hecht; D Lin; C B Chen
Journal:  Carcinogenesis       Date:  1981       Impact factor: 4.944

6.  The mutagenicity of nitrosamides in Salmonella typhimurium.

Authors:  W Lijinsky; A W Andrews
Journal:  Mutat Res       Date:  1979-09       Impact factor: 2.433

7.  Acute nonlymphocytic leukemia associated with nitrosourea chemotherapy: report of two cases.

Authors:  R J Cohen; P H Wiernik; M D Walker
Journal:  Cancer Treat Rep       Date:  1976-09

8.  Alpha-hydroxylation in the metabolism of N-nitrosopiperidine by rat liver microsomes: formation of 5-hydroxypentanal.

Authors:  K H Leung; K K Park; M C Archer
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1978-02

9.  Problems of dose-response studies in chemical carcinogenesis with special reference to N-nitroso compounds.

Authors:  D Schmähl
Journal:  CRC Crit Rev Toxicol       Date:  1979-08

10.  [On the carcinogenic action of N-nitroso compounds. 6th communication: methoxymethyl-methylnitrosamine, 1-(methoxy)-ethyl-ethylnitrosamine, methoxymethyl-ethylnitrosamine, 1-(methoxy)-ethyl-methylnitrosamine, and N-nitrosooxazolidine (author's transl)].

Authors:  M Wiessler; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-12-20
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  3 in total

Review 1.  Assessing the safety of drugs for the long-term treatment of peptic ulcers.

Authors:  K G Wormsley
Journal:  Gut       Date:  1984-12       Impact factor: 23.059

Review 2.  The formation and biological significance of N7-guanine adducts.

Authors:  Gunnar Boysen; Brian F Pachkowski; Jun Nakamura; James A Swenberg
Journal:  Mutat Res       Date:  2009-05-22       Impact factor: 2.433

3.  Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer.

Authors:  M Mrkonjic; E Chappell; V V Pethe; M Manno; D Daftary; C M Greenwood; S Gallinger; B W Zanke; J A Knight; B Bapat
Journal:  Br J Cancer       Date:  2009-05-19       Impact factor: 7.640
  3 in total

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