Literature DB >> 148095

Alpha-hydroxylation in the metabolism of N-nitrosopiperidine by rat liver microsomes: formation of 5-hydroxypentanal.

K H Leung, K K Park, M C Archer.   

Abstract

Metabolism of n-nitrosopiperidine by a purified microsomal preparation from rat liver was shown to yield 5-hydroxypentanal. This is the predicted product for a pathway involving an initial oxidation of the nitrosamine at the carbon atom alpha to the nitroso group.

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Year:  1978        PMID: 148095

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN: 0034-5164


  3 in total

Review 1.  Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed.

Authors:  Yupeng Li; Stephen S Hecht
Journal:  Int J Mol Sci       Date:  2022-04-20       Impact factor: 6.208

Review 2.  Carcinogenic N-nitroso compounds and their environmental significance.

Authors:  R Preussmann
Journal:  Naturwissenschaften       Date:  1984-01

3.  alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-N-methylaniline.

Authors:  M B Kroeger-Koepke; S R Koepke; G A McClusky; P N Magee; C J Michejda
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

  3 in total

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