| Literature DB >> 6339944 |
Abstract
Some frameshift mutations are strongly suppressed by limitation for particular aminoacyl-tRNA species. Here, we show that ribosome frameshifting at a specific tryptophan codon during Trp-tRNA limitation accounts for suppression of a group of downstream frameshift alleles in the rIIB gene of bacteriophage T4. Genetic and physiological observations strongly suggest that ribosome frameshifting at this position depends on the binding of a noncognate (leucine) tRNA.Entities:
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Year: 1983 PMID： 6339944 DOI： 10.1038/302389a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962