Literature DB >> 6333871

The active site of the P99 beta-lactamase from Enterobacter cloacae.

B Joris, J Dusart, J M Frere, J van Beeumen, E L Emanuel, S Petursson, J Gagnon, S G Waley.   

Abstract

Labelling the beta-lactamase of Enterobacter cloacae P99 with a poor substrate or a mechanism-based inactivator points to an active-site serine residue in a sequence closely resembling that of the ampC beta-lactamase. These results establish the P99 enzyme as a class-C beta-lactamase, and the concurrence of the two approaches helps to confirm the reliability of determining active-site sequences with the aid of mechanism-based inactivators.

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Year:  1984        PMID： 6333871      PMCID： PMC1144291          DOI： 10.1042/bj2230271

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Beta-lactamase (Enterobacter species).

Authors:  G W Ross
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  The use of logarithmic plots of electrophoretic mobilities of peptides.

Authors:  R E Offord
Journal:  Methods Enzymol       Date:  1977       Impact factor: 1.600

3.  6 beta-Bromopenicillanic acid inactivates beta-lactamase I.

Authors:  V Knott-Hunziker; B S Orlek; P G Sammes; S G Waley
Journal:  Biochem J       Date:  1979-01-01       Impact factor: 3.857

4.  Chemical studies on methionyl-tRNA synthetase from Escherichia coli.

Authors:  C J Bruton; B S Hartley
Journal:  J Mol Biol       Date:  1970-09-14       Impact factor: 5.469

5.  ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

Authors:  B Jaurin; T Grundström
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

6.  beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin.

Authors:  J Fisher; J G Belasco; S Khosla; J R Knowles
Journal:  Biochemistry       Date:  1980-06-24       Impact factor: 3.162

7.  A gas-liquid solid phase peptide and protein sequenator.

Authors:  R M Hewick; M W Hunkapiller; L E Hood; W J Dreyer
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

8.  Rat brain Thy-1 glycoprotein. The amino acid sequence, disulphide bonds and an unusual hydrophobic region.

Authors:  D G Campbell; J Gagnon; K B Reid; A F Williams
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

9.  Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme.

Authors:  J Fisher; R L Charnas; S M Bradley; J R Knowles
Journal:  Biochemistry       Date:  1981-05-12       Impact factor: 3.162

10.  Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism.

Authors:  S A Cohen; R F Pratt
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162
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  21 in total

1.  ampR gene mutations that greatly increase class C beta-lactamase activity in Enterobacter cloacae.

Authors:  A Kuga; R Okamoto; M Inoue
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.

Authors:  N G Brown; T Palzkill
Journal:  Protein Eng Des Sel       Date:  2010-03-22       Impact factor: 1.650

Review 3.  Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'.

Authors:  K Bush
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191

4.  Inactivation of the thiol RTEM-1 beta-lactamase by 6-beta-bromopenicillanic acid. Identity of the primary active-site nucleophile.

Authors:  A K Knap; R F Pratt
Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857

5.  6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.

Authors:  F De Meester; J M Frère; S G Waley; S J Cartwright; R Virden; F Lindberg
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

6.  Evidence for an oxyanion hole in serine beta-lactamases and DD-peptidases.

Authors:  B P Murphy; R F Pratt
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

7.  Sequence and comparative analysis of three Enterobacter cloacae ampC beta-lactamase genes and their products.

Authors:  M Galleni; F Lindberg; S Normark; S Cole; N Honore; B Joris; J M Frere
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857

8.  Accumulation of acyl-enzyme intermediates during turnover of penicillins by the class A beta-lactamase of Staphylococcus aureus PC1.

Authors:  R F Pratt; T S McConnell; S J Murphy
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

9.  Carboxy groups as essential residues in beta-lactamases.

Authors:  C Little; E L Emanuel; J Gagnon; S G Waley
Journal:  Biochem J       Date:  1986-11-15       Impact factor: 3.857

10.  A survey of the kinetic parameters of class C beta-lactamases. Penicillins.

Authors:  M Galleni; J M Frère
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857
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