Literature DB >> 218563

6 beta-Bromopenicillanic acid inactivates beta-lactamase I.

V Knott-Hunziker, B S Orlek, P G Sammes, S G Waley.   

Abstract

The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.

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Year:  1979        PMID： 218563      PMCID： PMC1186377          DOI： 10.1042/bj1770365

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Isomerisation of benzyl 6-phenoxyacetoxypenicillanates and their S-oxides.

Authors:  E Roets; A Vlietinck; H Vanderhaeghe
Journal:  J Chem Soc Perkin 1       Date:  1976

2.  Substrate-induced deactivation of penicillinases. Studies of beta-lactamase I by hydrogen exchange.

Authors:  P A Kiener; S G Waley
Journal:  Biochem J       Date:  1977-08-01       Impact factor: 3.857

3.  The pH-dependence and group modification of beta-lactamase I.

Authors:  S G Waley
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

4.  A spectrophotometric assay of beta-lactamase action on penicillins.

Authors:  S G Waley
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

5.  Preliminary crystallographic data for beta-lactamase I from Bacillus cereus 569.

Authors:  R Aschaffenburg; D C Phillips; B J Sutton; G Baldwin; P A Kiener; S G Waley
Journal:  J Mol Biol       Date:  1978-04-15       Impact factor: 5.469

6.  Synthesis of tritium-labelled isopenicillin N, penicillin N and 6-aminopenicillanic acid.

Authors:  J J Usher; B Loder; E P Abraham
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

7.  The amino acid sequence of Staphylococcus aureus penicillinase.

Authors:  R P Ambler
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

8.  The partial amino acid sequence of the extracellular beta-lactamase I of Bacillus cereus 569/H.

Authors:  D R Thatcher
Journal:  Biochem J       Date:  1975-05       Impact factor: 3.857

9.  Reversible inhibitors of penicillinases.

Authors:  P A Kiener; S G Waley
Journal:  Biochem J       Date:  1978-01-01       Impact factor: 3.857

10.  Separation, purification and properties of beta-lactamase I and beta-lactamase II from Bacillus cereus 569/H/9.

Authors:  R B Davies; E P Abraham
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857
  10 in total
  13 in total

1.  Kinetic characterization of the acyl-enzyme mechanism for beta-lactamase I.

Authors:  M T Martin; S G Waley
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

Review 2.  Beta-lactamase inhibitors from laboratory to clinic.

Authors:  K Bush
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

Review 3.  Current challenges in antimicrobial chemotherapy: focus on ß-lactamase inhibition.

Authors:  Carine Bebrone; Patricia Lassaux; Lionel Vercheval; Jean-Sébastien Sohier; Adrien Jehaes; Eric Sauvage; Moreno Galleni
Journal:  Drugs       Date:  2010-04-16       Impact factor: 9.546

4.  Site-directed mutagenesis of beta-lactamase I: role of Glu-166.

Authors:  Y C Leung; C V Robinson; R T Aplin; S G Waley
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

5.  The active site of the P99 beta-lactamase from Enterobacter cloacae.

Authors:  B Joris; J Dusart; J M Frere; J van Beeumen; E L Emanuel; S Petursson; J Gagnon; S G Waley
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

Review 6.  Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics.

Authors:  H Ogawara
Journal:  Microbiol Rev       Date:  1981-12

7.  Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.

Authors:  Krisztina M Papp-Wallace; Magdalena Taracila; John M Hornick; Andrea M Hujer; Kristine M Hujer; Anne M Distler; Andrea Endimiani; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

8.  Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function.

Authors:  G Dalbadie-McFarland; L W Cohen; A D Riggs; C Morin; K Itakura; J H Richards
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

Review 9.  Three decades of the class A beta-lactamase acyl-enzyme.

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Curr Protein Pept Sci       Date:  2009-10       Impact factor: 3.272

10.  Purification of beta-lactamases by affinity chromatography on phenylboronic acid-agarose.

Authors:  S J Cartwright; S G Waley
Journal:  Biochem J       Date:  1984-07-15       Impact factor: 3.857
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