Literature DB >> 3264154

A survey of the kinetic parameters of class C beta-lactamases. Penicillins.

M Galleni1, J M Frère.   

Abstract

The interaction between six class C beta-lactamases and various penicillins has been studied. All the enzymes behaved in a very uniform manner. Benzylpenicillin exhibited relatively low kcat. values (14-75 s-1) but low values of Km resulted in high catalytic efficiencies [kcat./Km = 10 X 10(6)-75 X 10(6) M-1.s-1]. The kcat. values for ampicillin were 10-100-fold lower. Carbenicillin, oxacillin cloxacillin and methicillin were very poor substrates, exhibiting kcat. values between 1 x 10(-3) and 0.1 s-1. The Km values were correspondingly small. It could safely be hypothesized that, with all the tested substrates, deacylation was rate-limiting, resulting in acyl-enzyme accumulation.

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Year:  1988        PMID： 3264154      PMCID： PMC1135198          DOI： 10.1042/bj2550119

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

Review 1.  The beta-lactamases of gram-negative bacteria and their possible physiological role.

Authors:  M H Richmond; R B Sykes
Journal:  Adv Microb Physiol       Date:  1973       Impact factor: 3.517

2.  The active site of the P99 beta-lactamase from Enterobacter cloacae.

Authors:  B Joris; J Dusart; J M Frere; J van Beeumen; E L Emanuel; S Petursson; J Gagnon; S G Waley
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

3.  The pH-dependence of class B and class C beta-lactamases.

Authors:  R Bicknell; V Knott-Hunziker; S G Waley
Journal:  Biochem J       Date:  1983-07-01       Impact factor: 3.857

4.  Purification and properties of chromosomally mediated beta-lactamase from Citrobacter freundii GN7391.

Authors:  M Tajima; Y Takenouchi; S Sugawara; M Inoue; S Mitsuhashi
Journal:  J Gen Microbiol       Date:  1980-12

5.  ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

Authors:  B Jaurin; T Grundström
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

6.  Active sites of beta-lactamases. The chromosomal beta-lactamases of Pseudomonas aeruginosa and Escherichia coli.

Authors:  V Knott-Hunziker; S Petursson; G S Jayatilake; S G Waley; B Jaurin; T Grundström
Journal:  Biochem J       Date:  1982-03-01       Impact factor: 3.857

7.  A survey of the kinetic parameters of class C beta-lactamases. Cephalosporins and other beta-lactam compounds.

Authors:  M Galleni; G Amicosante; J M Frère
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

8.  Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams.

Authors:  H Vu; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

9.  Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.

Authors:  K Bush; S K Tanaka; D P Bonner; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

Review 10.  beta-Lactamase inhibitors.

Authors:  S J Cartwright; S G Waley
Journal:  Med Res Rev       Date:  1983 Oct-Dec       Impact factor: 12.944
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  37 in total

1.  Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams.

Authors:  A Mazzariol; G Cornaglia; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

2.  CENTA as a chromogenic substrate for studying beta-lactamases.

Authors:  C Bebrone; C Moali; F Mahy; S Rival; J D Docquier; G M Rossolini; J Fastrez; R F Pratt; J M Frère; M Galleni
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

3.  Chemical complementation: a reaction-independent genetic assay for enzyme catalysis.

Authors:  Kathleen Baker; Colleen Bleczinski; Hening Lin; Gilda Salazar-Jimenez; Debleena Sengupta; Sonja Krane; Virginia W Cornish
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-13       Impact factor: 11.205

4.  Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.

Authors:  Shalom D Goldberg; William Iannuccilli; Tuan Nguyen; Jingyue Ju; Virginia W Cornish
Journal:  Protein Sci       Date:  2003-08       Impact factor: 6.725

5.  Importance of the two tryptophan residues in the Streptomyces R61 exocellular DD-peptidase.

Authors:  C Bourguignon-Bellefroid; J M Wilkin; B Joris; R T Aplin; C Houssier; F G Prendergast; J Van Beeumen; J M Ghuysen; J M Frère
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

Review 6.  Characterization of beta-lactamases.

Authors:  K Bush
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191

7.  Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase.

Authors:  Scott T Lefurgy; René M de Jong; Virginia W Cornish
Journal:  Protein Sci       Date:  2007-12       Impact factor: 6.725

8.  Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.

Authors:  Siew Ping Lim; Hiroshi Nikaido
Journal:  Antimicrob Agents Chemother       Date:  2010-02-16       Impact factor: 5.191

9.  Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels.

Authors:  Seiji Kojima; Hiroshi Nikaido
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-24       Impact factor: 11.205

10.  A survey of the kinetic parameters of class C beta-lactamases. Cephalosporins and other beta-lactam compounds.

Authors:  M Galleni; G Amicosante; J M Frère
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857
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