Literature DB >> 6329738

The chromosomal integration site determines the tissue-specific methylation of mouse mammary tumour virus proviral genes.

W H Günzburg, B Groner.   

Abstract

Multiple endogenous mouse mammary tumour virus (MMTV) proviral genes are present at different chromosomal locations in inbred mouse strains. Proviral DNA methylation is location and tissue specific. The methylation patterns are stably inherited and appear to be conferred upon the viral DNA by the flanking mouse genomic DNA. In transformed cells, either mammary carcinoma cells, or cells immortalized by SV40 in vitro, the stable pattern of methylation is lost. Although hypomethylation of proviral genes, both in normal and in transformed tissue, accompanies MMTV-specific RNA expression, it is also observed in non-expressing tissues.

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Year:  1984        PMID： 6329738      PMCID： PMC557485          DOI： 10.1002/j.1460-2075.1984.tb01941.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  49 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Identification of the Mtv-2 gene responsible for the early appearance of mammary tumors in the GR mouse by nucleic acid hybridization.

Authors:  R Michalides; L van Deemter; R R Nuss; R van Nie
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

3.  Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone.

Authors:  G M Ringold; P R Shank; K R Yamamoto
Journal:  J Virol       Date:  1978-04       Impact factor: 5.103

4.  Distribution of 5-methylcytosine in chromatin.

Authors:  A Razin; H Cedar
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

5.  5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result.

Authors:  J N Lapeyre; F F Becker
Journal:  Biochem Biophys Res Commun       Date:  1979-04-13       Impact factor: 3.575

6.  DNA methylation in normal and tumour virus-transformed cells in tissue culture. I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells).

Authors:  E D Rubery; A A Newton
Journal:  Biochim Biophys Acta       Date:  1973-09-28

7.  MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites.

Authors:  C Waalwijk; R A Flavell
Journal:  Nucleic Acids Res       Date:  1978-09       Impact factor: 16.971

8.  DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations.

Authors:  C Waalwijk; R A Flavell
Journal:  Nucleic Acids Res       Date:  1978-12       Impact factor: 16.971

9.  Integrated simian virus 40 sequences in transformed cell DNA: analysis using restriction endonucleases.

Authors:  G Ketner; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

10.  DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

Authors:  M Wigler; A Pellicer; S Silverstein; R Axel; G Urlaub; L Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205
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  18 in total

Review 1.  Factors controlling the expression of mouse mammary tumour virus.

Authors:  W H Günzburg; B Salmons
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

2.  Analysis of tissue-specific methylation patterns of mouse mammary tumor virus DNA by two-dimensional Southern blotting.

Authors:  T G Fanning; W S Hu; R D Cardiff
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

3.  Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome.

Authors:  T G Fanning; D W Morris; R D Cardiff; H D Bradshaw
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

4.  Differential expression of endogenous mouse mammary tumor virus genes during development of the BALB/c mammary gland.

Authors:  J E Knepper; D Medina; J S Butel
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

5.  Genome-wide methylation analysis of retrocopy-associated CpG islands and their genomic environment.

Authors:  Katrin Grothaus; Deniz Kanber; Alexandra Gellhaus; Barbara Mikat; Julia Kolarova; Reiner Siebert; Dagmar Wieczorek; Bernhard Horsthemke
Journal:  Epigenetics       Date:  2016-02-18       Impact factor: 4.528

6.  A correlation between dexamethasone inducibility and basal expression levels of retroviral vector proviruses.

Authors:  M Duch; K Paludan; J Lovmand; L Pedersen; P Jørgensen; F S Pedersen
Journal:  Nucleic Acids Res       Date:  1993-10-11       Impact factor: 16.971

7.  Nonrandom distribution of MMTV proviral sequences in the mouse genome.

Authors:  J Salinas; M Zerial; J Filipski; M Crepin; G Bernardi
Journal:  Nucleic Acids Res       Date:  1987-04-10       Impact factor: 16.971

8.  Mammary gland-specific hypomethylation of Hpa II sites flanking the bovine alpha S1-casein gene.

Authors:  G J Platenburg; E J Vollebregt; C N Karatzas; E P Kootwijk; H A De Boer; R Strijker
Journal:  Transgenic Res       Date:  1996-11       Impact factor: 2.788

9.  Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development.

Authors:  D Jähner; R Jaenisch
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272

10.  Lack of correlation between basal expression levels and susceptibility to transcriptional shutdown among single-gene murine leukemia virus vector proviruses.

Authors:  M Duch; K Paludan; P Jørgensen; F S Pedersen
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103
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