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Literature DB >> 268622

Distribution of 5-methylcytosine in chromatin.

Abstract

The content of 5-methylcytosine in eukaryotic DNA was measured by mass spectrometry. Almost equal amounts of methylated cytosine were found in the DNA of various tissues of the chicken. When chromatin or nuclei were digested with micrococcal nuclease, 50% of the DNA was found to be nuclease resistant. In contrast to this, over 75% of the 5-methylcytosine was protected from nuclease digestion by chromatin proteins. These results suggest that 5-methylcytosine is nonrandomly distributed with respect to the nucleoproteins.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1977 PMID： 268622 PMCID： PMC431263 DOI： 10.1073/pnas.74.7.2725

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

29 in total

1. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

Authors: A Garel; R Axel
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

2. Analysis of DNA of isolated chromatin subunits.

Authors: E Lacy; R Axel
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

3. Studies on the biological role of DNA methylation. II. Role of phiX174 DNA methylation in the process of viral progeny DNA synthesis.

Authors: J Friedman; A Razin
Journal: Nucleic Acids Res Date: 1976-10 Impact factor: 16.971

Distribution of 5-methylcytosine in chromatin.

1. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

2. Analysis of DNA of isolated chromatin subunits.

3. Studies on the biological role of DNA methylation. II. Role of phiX174 DNA methylation in the process of viral progeny DNA synthesis.

4. The nucleic acids of Rickettsia burneti.

5. The globin gene: structure and expression.

6. Spheroid chromatin units (v bodies).

7. Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro.

8. Structure of chromatin.

9. Nonhistone proteins control gene expression in reconstituted chromatin.

10. Restriction endonuclease cleavage of satellite DNA in intact bovine nuclei.

1. Methylation of adenine in the nuclear DNA of Tetrahymena is internucleosomal and independent of histone H1.

2. Deoxyribonucleic acid methylation and chromatin organization in Tetrahymena thermophila.

3. Enzymes used in molecular biology: a useful guide.

4. Inhibition of condensation in human chromosomes induced by the thymidine analogue 5-iododeoxyuridine.

5. Co-operative interactions of oligonucleosomal DNA with the H1e histone variant and its poly(ADP-ribosyl)ated isoform.

Review 6. CpG methylation, chromatin structure and gene silencing-a three-way connection.

7. The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation.

Review 8. Identifying 5-methylcytosine and related modifications in DNA genomes.

9. Tissue specificity and clustering of methylated cystosines in bovine satellite I DNA.

10. Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons.