Literature DB >> 6317415

Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin.

E S Vizi, N Ludvig, A Z Rónai, G Folly.   

Abstract

Evidence has been obtained that prazosin possesses a presynaptic alpha 2-adrenoceptor blocking action in the rat was deferens preparation stimulated at 1 Hz. In the presence of prazosin yohimbine failed to affect the presynaptic alpha 2-adrenoceptor stimulatory effect of 1-noradrenaline while the effect of xylazine was almost completely abolished. It is therefore suggested that there are two kinetically different prejunctional alpha 2-adrenoceptor sites.

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Year:  1983        PMID： 6317415     DOI： 10.1016/0014-2999(83)90648-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Characterization of pigment aggregating alpha 2-adrenoceptors of fish melanophores by use of different agonists after partial irreversible receptor inactivation.

Authors:  J O Karlsson; R G Andersson; N Grundström
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

2.  Neurochemical evidence for two types of presynaptic alpha 2-adrenoceptors.

Authors:  J Kapocsi; G T Somogyi; N Ludvig; P Serfozo; L G Harsing; R J Woods; E S Vizi
Journal:  Neurochem Res       Date:  1987-02       Impact factor: 3.996

3.  Proceedings of the British Pharmacological Society. London, 17th-19th December, 1984. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1985-03       Impact factor: 8.739

4.  Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.

Authors:  R A Bond; K G Charlton; D E Clarke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000

5.  Prazosin partly blocks clonidine-induced hypotension in patients with essential hypertension.

Authors:  J Kapocsi; C Farsang; E S Vizi
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

6.  Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens.

Authors:  P E Hicks; S Z Langer; A D Macrae
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

7.  A response to isoprenaline unrelated to alpha- and beta-adrenoceptor agonism.

Authors:  R A Bond; D E Clarke
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

8.  Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina.

Authors:  K Wypijewski; T Duda; R K Sharma
Journal:  Mol Cell Biochem       Date:  1995-03-23       Impact factor: 3.396
  8 in total

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