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Literature DB >> 3033532

Neurochemical evidence for two types of presynaptic alpha 2-adrenoceptors.

J Kapocsi, G T Somogyi, N Ludvig, P Serfozo, L G Harsing, R J Woods, E S Vizi.

Abstract

Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha 2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha 2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha 2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha 2-adrenoceptors at the presynaptic axon terminals.

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Year: 1987 PMID： 3033532 DOI： 10.1007/BF00979530

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

29 in total

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Journal: Eur J Pharmacol Date: 1978-11-01 Impact factor: 4.432

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12 in total

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Authors: K Smith; S Connaughton; J R Docherty
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Journal: Br J Pharmacol Date: 1988-10 Impact factor: 8.739

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Journal: Br J Pharmacol Date: 1991-06 Impact factor: 8.739

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Authors: G Tarkovács; C Blandizzi; E S Vizi
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1994-01 Impact factor: 3.000

5. Neuropeptide Y neuromodulation of sympathetic co-transmission in the guinea-pig vas deferens.

Authors: J L Ellis; G Burnstock
Journal: Br J Pharmacol Date: 1990-07 Impact factor: 8.739

6. Angiotensin neuromodulation of adrenergic and purinergic co-transmission in the guinea-pig vas deferens.

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7. Prejunctional facilitatory alpha 1-adrenoceptors in the rat urinary bladder.

Authors: G T Somogyi; M Tanowitz; W C de Groat
Journal: Br J Pharmacol Date: 1995-04 Impact factor: 8.739

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Authors: G Maura; G Bonanno; M Raiteri
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-04 Impact factor: 3.000

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Authors: G T Somogyi; M Tanowitz; W C de Groat
Journal: J Physiol Date: 1994-10-01 Impact factor: 5.182

10. Functional characterization of neuronal pre and postsynaptic alpha 2-adrenoceptor subtypes in guinea-pig submucosal plexus.

Authors: K Z Shen; C Barajas-Lopez; A Surprenant
Journal: Br J Pharmacol Date: 1990-12 Impact factor: 8.739