Literature DB >> 6312932

Antiviral effects of bacteria-derived human leukocyte interferons against encephalomyocarditis virus infection of squirrel monkeys. Brief report.

N Stebbing, P K Weck, J T Fenno, D A Estell, E Rinderknecht.   

Abstract

Two human leukocyte interferon sub-types (IFN-alpha A and -alpha D) produced in E. coli and a hybrid interferon (IFN-alpha AD[Bgl]) consisting of the N-terminal 61 residues of IFN-alpha A and the C-terminal 104 residues of IFN-alpha D were compared for antiviral activity against EMC virus infection of squirrel monkeys. Marked reduction in viremia and a decrease in the incidence of deaths occurred with highly purified preparations of the recombinant-DNA derived interferons. Dose response studies showed that IFN-alpha D and -alpha AD (Bgl) were more effective than IFN-alpha A.

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Year:  1983        PMID： 6312932     DOI： 10.1007/bf01311204

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  14 in total

1.  Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data.

Authors:  R Peto; M C Pike
Journal:  Biometrics       Date:  1973-09       Impact factor: 2.571

2.  The structure of eight distinct cloned human leukocyte interferon cDNAs.

Authors:  D V Goeddel; D W Leung; T J Dull; M Gross; R M Lawn; R McCandliss; P H Seeburg; A Ullrich; E Yelverton; P W Gray
Journal:  Nature       Date:  1981-03-05       Impact factor: 49.962

3.  Comparative antiviral efficiency of leukocyte and bacterially produced human alpha-interferon in rhesus monkeys.

Authors:  H Schellekens; A de Reus; R Bolhuis; M Fountoulakis; C Schein; J Ecsödi; S Nagata; C Weissmann
Journal:  Nature       Date:  1981-08-20       Impact factor: 49.962

4.  The inadequacy of rectal temperature measurements for assessing the effects of antiviral drugs on influenza virus infection of ferrets.

Authors:  N Stebbing; G F Healey; E M Round
Journal:  J Virol Methods       Date:  1982-12       Impact factor: 2.014

5.  Synthesis in E. coli of a polypeptide with human leukocyte interferon activity.

Authors:  S Nagata; H Taira; A Hall; L Johnsrud; M Streuli; J Ecsödi; W Boll; K Cantell; C Weissmann
Journal:  Nature       Date:  1980-03-27       Impact factor: 49.962

6.  Stimulation of natural killer cell activity and inhibition of proliferation of various leukemic cells by purified human leukocyte interferon subtypes.

Authors:  S H Lee; S Kelley; H Chiu; N Stebbing
Journal:  Cancer Res       Date:  1982-04       Impact factor: 12.701

7.  Antiviral activities of hybrids of two major human leukocyte interferons.

Authors:  P K Weck; S Apperson; N Stebbing; P W Gray; D Leung; H M Shepard; D V Goeddel
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

8.  Comparison of the antiviral activities of various cloned human interferon-alpha subtypes in mammalian cell cultures.

Authors:  P K Weck; S Apperson; L May; N Stebbing
Journal:  J Gen Virol       Date:  1981-11       Impact factor: 3.891

9.  Antiviral activity of bacteria-derived human alpha interferons against encephalomyocarditis virus infection of mice.

Authors:  P K Weck; E Rinderknecht; D A Estell; N Stebbing
Journal:  Infect Immun       Date:  1982-02       Impact factor: 3.441

10.  Human leukocyte interferon produced by E. coli is biologically active.

Authors:  D V Goeddel; E Yelverton; A Ullrich; H L Heyneker; G Miozzari; W Holmes; P H Seeburg; T Dull; L May; N Stebbing; R Crea; S Maeda; R McCandliss; A Sloma; J M Tabor; M Gross; P C Familletti; S Pestka
Journal:  Nature       Date:  1980-10-02       Impact factor: 49.962
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  1 in total

Review 1.  Preclinical safety testing of species-specific proteins produced with recombinant DNA-techniques. An attempt to transfer current experience into future testing strategies.

Authors:  K Teelmann; C Hohbach; H Lehmann
Journal:  Arch Toxicol       Date:  1986-12       Impact factor: 5.153
  1 in total

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