Literature DB >> 6310515

Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.

G Raugei, G Bensi, V Colantuoni, V Romano, C Santoro, F Costanzo, R Cortese.   

Abstract

We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

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Year:  1983        PMID： 6310515      PMCID： PMC326319          DOI： 10.1093/nar/11.17.5811

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  20 in total

1.  Haptoglobin sub-types in three racial groups.

Authors:  E R GIBLETT; L E BROOKS
Journal:  Nature       Date:  1963-02-09       Impact factor: 49.962

2.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

3.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

4.  pEMBL: a new family of single stranded plasmids.

Authors:  L Dente; G Cesareni; R Cortese
Journal:  Nucleic Acids Res       Date:  1983-03-25       Impact factor: 16.971

5.  Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.

Authors:  A J Mason; B A Evans; D R Cox; J Shine; R I Richards
Journal:  Nature       Date:  1983-05-26       Impact factor: 49.962

Review 6.  Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation.

Authors:  B H Bowman; A Kurosky
Journal:  Adv Hum Genet       Date:  1982

7.  Isolation and characterization of a cDNA coding for human factor IX.

Authors:  K Kurachi; E W Davie
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

8.  An improved haptoglobin subtyping procedure using polyacrylamide gel electrophoresis. Haptoglobin gene frequency distribution among a group of blood bank donors.

Authors:  J V Pastewka; R A Reed; A T Ness; A C Peacock
Journal:  Anal Biochem       Date:  1973-01       Impact factor: 3.365

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Cloning of several cDNA segments coding for human liver proteins.

Authors:  F Costanzo; L Castagnoli; L Dente; P Arcari; M Smith; P Costanzo; G Raugei; P Izzo; T C Pietropaolo; L Bougueleret; F Cimino; F Salvatore; R Cortese
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  22 in total

1.  Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.

Authors:  L Dente; G Ciliberto; R Cortese
Journal:  Nucleic Acids Res       Date:  1985-06-11       Impact factor: 16.971

2.  The cytokine response element of the rat alpha 1-acid glycoprotein gene is a complex of several interacting regulatory sequences.

Authors:  K A Won; H Baumann
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

3.  A new restriction fragment length polymorphism in the haptoglobin gene region.

Authors:  S Oliviero; M DeMarchi; G Bensi; G Raugei; A O Carbonara
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Molecular evidence of triplication in the haptoglobin Johnson variant gene.

Authors:  S Oliviero; M DeMarchi; A O Carbonara; L F Bernini; G Bensi; G Raugei
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

5.  A population genetic survey of the haptoglobin polymorphism in Melanesians by DNA analysis.

Authors:  A V Hill; D K Bowden; J Flint; D B Whitehouse; D A Hopkinson; S J Oppenheimer; S W Serjeantson; J B Clegg
Journal:  Am J Hum Genet       Date:  1986-03       Impact factor: 11.025

6.  Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.

Authors:  H Baumann; H Isseroff; J J Latimer; G P Jahreis
Journal:  J Biol Chem       Date:  1988-11-25       Impact factor: 5.157

7.  The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII.

Authors:  F J Castellino; J M Beals
Journal:  J Mol Evol       Date:  1987       Impact factor: 2.395

8.  Identification of an uncommon haptoglobin type using DNA and protein analysis.

Authors:  S L Marles; P J McAlpine; T Zelinski; S Phillips; N Maeda; C R Greenberg
Journal:  Hum Genet       Date:  1993-10       Impact factor: 4.132

9.  Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.

Authors:  M C Cid; D S Grant; G S Hoffman; R Auerbach; A S Fauci; H K Kleinman
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

10.  The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.

Authors:  I Henry; G Uzan; D Weil; H Nicolas; J C Kaplan; C Marguerie; A Kahn; C Junien
Journal:  Am J Hum Genet       Date:  1984-07       Impact factor: 11.025
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