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Literature DB >> 6089549

The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.

I Henry, G Uzan, D Weil, H Nicolas, J C Kaplan, C Marguerie, A Kahn, C Junien.

Abstract

We used cloned cDNA probes for the A alpha-, B beta-, and gamma-chains of human fibrinogen and Southern blotting techniques to analyze DNA from a series of rodent X human somatic cell hybrids for the presence of specific fibrinogen-related sequences. Our results provide evidence for the assignment of the three genes for fibrinogen to chromosome 4. Moreover, by direct gene-dosage determination in two patients with chromosome 4 unbalanced rearrangements, we refined the regional chromosomal assignment to 4q2, thus suggesting that these three genes whose expression is coordinately regulated are closely linked.

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Year: 1984 PMID： 6089549 PMCID： PMC1684488

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

22 in total

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Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

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Authors: A Z Budzynski; V J Marder; D Ménaché; M C Guillin
Journal: Nature Date: 1974-11-01 Impact factor: 49.962

3. Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain.

Authors: M L Chu; J C Myers; M P Bernard; J F Ding; F Ramirez
Journal: Nucleic Acids Res Date: 1982-10-11 Impact factor: 16.971

4. A molecular map of the immune response region from the major histocompatibility complex of the mouse.

Authors: M Steinmetz; K Minard; S Horvath; J McNicholas; J Srelinger; C Wake; E Long; B Mach; L Hood
Journal: Nature Date: 1982-11-04 Impact factor: 49.962

5. Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization.

Authors: C Junien; D Weil; J C Myers; N Van Cong; M L Chu; C Foubert; M S Gross; D J Prockop; J C Kaplan; F Ramirez
Journal: Am J Hum Genet Date: 1982-05 Impact factor: 11.025

6. The rat fibrinogen genes. Linkage of the A alpha and gamma chain genes.

Authors: J A Kant; G R Crabtree
Journal: J Biol Chem Date: 1983-04-25 Impact factor: 5.157

7. Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.

Authors: J A Kant; S T Lord; G R Crabtree
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

8. Fibrinogen gamma chain locus is on chromosome 4 in man.

Authors: B Olaisen; P Teisberg; T Gedde-Dahl
Journal: Hum Genet Date: 1982 Impact factor: 4.132

9. Direct gene dosage determination in patients with unbalanced chromosomal aberrations using cloned DNA sequences. Application to the regional assignment of the gene for alpha 2(I) procollagen (COLIA2).

Authors: C Junien; C Huerre; M O Rethoré
Journal: Am J Hum Genet Date: 1983-07 Impact factor: 11.025

10. Coordinate accumulation of the mRNAs for the alpha, beta, and gamma chains of rat fibrinogen following defibrination.

Authors: G R Crabtree; J A Kant
Journal: J Biol Chem Date: 1982-07-10 Impact factor: 5.157

20 in total

Review 1. Comparative map for mice and humans.

Authors: J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

Authors: Z Rahmani; J L Blouin; N Creau-Goldberg; P C Watkins; J F Mattei; M Poissonnier; M Prieur; Z Chettouh; A Nicole; A Aurias
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

3. Extended haplotypes and linkage disequilibrium between 11 markers at the APOA1-C3-A4 gene cluster on chromosome 11.

Authors: P Benlian; C Boileau; N Loux; D Pastier; J Masliah; M Coulon; M Nigou; A Ragab; J Guimard; J B Ruidavets
Journal: Am J Hum Genet Date: 1991-05 Impact factor: 11.025

Review 4. Comparative map for mice and humans.

Authors: J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

5. Linkage analysis of five fibrillar collagen loci in a large French Marfan syndrome family.

Authors: C Boileau; G Jondeau; C Bonaiti; M Coulon; G Delorme; O Dubourg; J P Bourdarias; C Junien
Journal: J Med Genet Date: 1990-02 Impact factor: 6.318

Review 6. Fibrinogen alpha amyloidosis: insights from proteomics.

Authors: Jessica Chapman; Ahmet Dogan
Journal: Expert Rev Proteomics Date: 2019-08-28 Impact factor: 3.940

7. Recurrent mutation at aa 792 in the LDL receptor gene in a French patient.

Authors: N Loux; P Benlian; D Pastier; C Boileau; J P Cambou; L Monnier; C Percheron; C Junien
Journal: Hum Genet Date: 1991-07 Impact factor: 4.132

8. Autosomal dominant Marfan-like connective-tissue disorder with aortic dilation and skeletal anomalies not linked to the fibrillin genes.

Authors: C Boileau; G Jondeau; M C Babron; M Coulon; J A Alexandre; L Sakai; J Melki; G Delorme; O Dubourg; C Bonaïti-Pellié
Journal: Am J Hum Genet Date: 1993-07 Impact factor: 11.025

9. Fibrinogen Manchester. Detection of a heterozygous phenotype in the intraplatelet pool.

Authors: C Southan; D A Lane; I Knight; H Ireland; J Bottomley
Journal: Biochem J Date: 1985-08-01 Impact factor: 3.857

10. Myotonic dystrophy: size- and sex-dependent dynamics of CTG meiotic instability, and somatic mosaicism.

Authors: C Lavedan; H Hofmann-Radvanyi; P Shelbourne; J P Rabes; C Duros; D Savoy; I Dehaupas; S Luce; K Johnson; C Junien
Journal: Am J Hum Genet Date: 1993-05 Impact factor: 11.025