Literature DB >> 6309261

The effect of receptor clustering on diffusion-limited forward rate constants.

B Goldstein, F W Wiegel.   

Abstract

The effect of receptor clustering on the diffusion-limited forward rate constant (k+) is studied theoretically by modeling cell surface receptors by hemispheres distributed on a plane. We give both exact results and bounds. The exact results are obtained using an electrostatic analogue and applying the method of the images. Accurate upper bounds on k+ are found from a variational principle.

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Year:  1983        PMID： 6309261      PMCID： PMC1329275          DOI： 10.1016/S0006-3495(83)84330-6

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  9 in total

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Authors:  R E Pitas; T L Innerarity; K S Arnold; R W Mahley
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

2.  Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts.

Authors:  R G Anderson; M S Brown; J L Goldstein
Journal:  Cell       Date:  1977-03       Impact factor: 41.582

3.  Physics of chemoreception.

Authors:  H C Berg; E M Purcell
Journal:  Biophys J       Date:  1977-11       Impact factor: 4.033

Review 4.  The biophysics of ligand-receptor interactions.

Authors:  C DeLisi
Journal:  Q Rev Biophys       Date:  1980-05       Impact factor: 5.318

5.  Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions.

Authors:  C DeLisi; F W Wiegel
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

6.  Role of diffusion in ligand binding to macromolecules and cell-bound receptors.

Authors:  D Shoup; A Szabo
Journal:  Biophys J       Date:  1982-10       Impact factor: 4.033

7.  Coated pits, coated vesicles, and receptor-mediated endocytosis.

Authors:  J L Goldstein; R G Anderson; M S Brown
Journal:  Nature       Date:  1979-06-21       Impact factor: 49.962

8.  Subunit structure and dynamics of the insulin receptor.

Authors:  M P Czech; J Massague
Journal:  Fed Proc       Date:  1982-09

9.  Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes.

Authors:  L Jarett; J B Schweitzer; R M Smith
Journal:  Science       Date:  1980-12-05       Impact factor: 47.728
  9 in total
  13 in total

1.  A thermodynamic model for receptor clustering.

Authors:  C Guo; H Levine
Journal:  Biophys J       Date:  1999-11       Impact factor: 4.033

2.  Communication: Clusters of absorbing disks on a reflecting wall: competition for diffusing particles.

Authors:  Alexander M Berezhkovskii; Leonardo Dagdug; Vladimir A Lizunov; Joshua Zimmerberg; Sergey M Bezrukov
Journal:  J Chem Phys       Date:  2012-06-07       Impact factor: 3.488

Review 3.  Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action.

Authors:  Georges Vauquelin; Steven J Charlton
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

4.  Effects of receptor clustering on ligand dissociation kinetics: theory and simulations.

Authors:  Manoj Gopalakrishnan; Kimberly Forsten-Williams; Matthew A Nugent; Uwe C Täuber
Journal:  Biophys J       Date:  2005-09-08       Impact factor: 4.033

5.  The rate of internalization of different receptor-ligand complexes in alveolar macrophages is receptor-specific.

Authors:  D M Ward; J Kaplan
Journal:  Biochem J       Date:  1990-09-01       Impact factor: 3.857

6.  T cell receptors adapt by spacing out.

Authors:  Michael L Dustin
Journal:  Biophys J       Date:  2012-11-07       Impact factor: 4.033

7.  Trapping of diffusing particles by clusters of absorbing disks on a reflecting wall with disk centers on sites of a square lattice.

Authors:  Alexander M Berezhkovskii; Leonardo Dagdug; Marco-Vinicio Vazquez; Vladimir A Lizunov; Joshua Zimmerberg; Sergey M Bezrukov
Journal:  J Chem Phys       Date:  2013-02-14       Impact factor: 3.488

Review 8.  Trapping by clusters of channels, receptors, and transporters: quantitative description.

Authors:  Alexander M Berezhkovskii; Leonardo Dagdug; Vladimir A Lizunov; Joshua Zimmerberg; Sergey M Bezrukov
Journal:  Biophys J       Date:  2014-02-04       Impact factor: 4.033

9.  The effect of receptor density on the forward rate constant for binding of ligands to cell surface receptors.

Authors:  J Erickson; B Goldstein; D Holowka; B Baird
Journal:  Biophys J       Date:  1987-10       Impact factor: 4.033

10.  Kinetics of ligand binding to a cluster of membrane-associated receptors.

Authors:  A A Potanin; V V Verkhusha; O S Belokoneva; F W Wiegel
Journal:  Eur Biophys J       Date:  1994       Impact factor: 1.733
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