Literature DB >> 6295917

Intracellular distribution of DNA topoisomerase I in fibroblasts from patients with Fanconi's anaemia.

B Auer, H P Vosberg, U Buhre, H Klocker, M Hirsch-Kauffmann, M Schweiger.   

Abstract

The activity of DNA topoisomerase I(DNA nicking-closing enzyme) was analysed in cytoplasmic and nuclear extracts of six independently derived Fanconi and four normal fibroblast cell lines. In all experiments the total cellular activity was predominantly found in the nuclear extracts (88-100%). In addition, a minor proportion of the enzyme (up to 12%) was randomly present in some of the cytoplasmic fractions of both Fanconi and normal fibroblasts. These results indicate that Fanconi's anaemia is probably not due to or accompanied by a maldistribution of topoisomerase I between nuclei and cytoplasm.

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Year:  1982        PMID： 6295917     DOI： 10.1007/bf00276603

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?

Authors:  M S Sasaki
Journal:  Nature       Date:  1975-10-09       Impact factor: 49.962

2.  Characterization of purified DNA-relaxing enzyme from human tissue culture cells.

Authors:  W Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

3.  DNA- and RNA-directed synthesis in vitro of phage enzymes.

Authors:  P Herrlich; M Schweiger
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

4.  Fanconi's anaemia in the genetics of neoplasia.

Authors:  M Swift
Journal:  Nature       Date:  1971-04-09       Impact factor: 49.962

5.  Chromosomal peculiarities and "in vitro" examinations in Fanconi's anaemia.

Authors:  D Schuler; A Kiss; F Fábián
Journal:  Humangenetik       Date:  1969

6.  Analysis of covalent complexes formed between calf thymus DNA topoisomerase and single-stranded DNA.

Authors:  B Prell; H P Vosberg
Journal:  Eur J Biochem       Date:  1980-07

7.  Carcinogen-induced chromosome breakage in Fanconi's anaemia heterozygous cells.

Authors:  A D Auerbach; S R Wolman
Journal:  Nature       Date:  1978-01-05       Impact factor: 49.962

8.  Deficiency of DNA ligase activity in Fanconi's anemia.

Authors:  M Hirsch-Kauffmann; M Schweiger; E F Wagner; K Sperling
Journal:  Hum Genet       Date:  1978-11-24       Impact factor: 4.132

9.  Genetic heterogeneity of Fanconi's anemia demonstrated by somatic cell hybrids.

Authors:  S Zakrzewski; K Sperling
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

10.  Fanconi's anemia: anomaly of enzyme passage through the nuclear membrane? Anomalous intracellular distribution of topoisomerase activity in placental extracts in a case of Fanconi's anemia.

Authors:  E Wunder; U Burghardt; B Lang; L Hamilton
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
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  9 in total

1.  Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons.

Authors:  Erez Eitan; Carmel Braverman; Ailone Tichon; Daniel Gitler; Emmette R Hutchison; Mark P Mattson; Esther Priel
Journal:  Cerebellum       Date:  2016-08       Impact factor: 3.847

2.  Modification of topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors.

Authors:  Refael Peleg; Marianna Romzova; Inga Kogan-Zviagin; Ron N Apte; Esther Priel
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3.  Complementation studies between Fanconi's anemia cells with different DNA repair characteristics.

Authors:  S Zakrzewski; M Koch; K Sperling
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

4.  Further studies on compartmentalisation of DNA-topoisomerase I in Fanconi anemia tissue.

Authors:  E Wunder
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells.

Authors:  H Youssoufian
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

6.  Topoisomerase I activity associated with human immunodeficiency virus (HIV) particles and equine infectious anemia virus core.

Authors:  E Priel; S D Showalter; M Roberts; S Oroszlan; S Segal; M Aboud; D G Blair
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

7.  DNA repair dependent NAD+ metabolism is impaired in cells from patients with Fanconi's anemia.

Authors:  H Klocker; B Auer; M Hirsch-Kauffmann; H Altmann; H J Burtscher; M Schweiger
Journal:  EMBO J       Date:  1983       Impact factor: 11.598

8.  Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis.

Authors:  Erez Eitan; Ailon Tichon; Aviv Gazit; Daniel Gitler; Shimon Slavin; Esther Priel
Journal:  EMBO Mol Med       Date:  2012-02-20       Impact factor: 12.137

9.  Mycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor.

Authors:  Reuven Afriat; Shulamith Horowitz; Esther Priel
Journal:  PLoS One       Date:  2013-08-27       Impact factor: 3.240
  9 in total

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