Literature DB >> 11894942

DNA repair dependent NAD+ metabolism is impaired in cells from patients with Fanconi's anemia.

H Klocker1, B Auer, M Hirsch-Kauffmann, H Altmann, H J Burtscher, M Schweiger.   

Abstract

In vitro cultivated fibroblasts derived either from patients with Fanconi's anemia (FA) or from healthy probands were analyzed for their DNA repair-dependent NAD+ metabolism. No difference in NAD+ pools was found. NAD+ consumption after cell damage by u.v. irradiation was, however, significantly reduced in FA cells. Several FA cell lines had a lowered ability to transfer ADP-ribose to acid-precipitable material. Additionally, a decreased activity of NAD: protein ADP-ribosyltransferase was found for three FA cell lines. Our data indicate, that FA is accompanied by a defective NAD+ metabolism during DNA repair.

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Year:  1983        PMID： 11894942      PMCID： PMC555133          DOI： 10.1002/j.1460-2075.1983.tb01423.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  44 in total

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Journal:  Z Kinderheilkd       Date:  1975-07-01

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Authors:  E G Miller
Journal:  Biochim Biophys Acta       Date:  1975-06-16

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Authors:  E G Miller
Journal:  Biochem Biophys Res Commun       Date:  1975-09-02       Impact factor: 3.575

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Authors:  M S Sasaki; A Tonomura
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

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Authors:  A Y Chang
Journal:  Biochim Biophys Acta       Date:  1972-01-28

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Authors:  P K Poon; R L O'Brien; J W Parker
Journal:  Nature       Date:  1974-07-19       Impact factor: 49.962

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Journal:  J Biol Chem       Date:  1969-04-10       Impact factor: 5.157

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Authors:  J X Khym
Journal:  Clin Chem       Date:  1975-08       Impact factor: 8.327

9.  Repair rate in human fibroblasts measured by thymine dimer excorporation.

Authors:  H Klocker; B Auer; H J Burtscher; M Hirsch-Kauffmann; M Schweiger
Journal:  Mol Gen Genet       Date:  1982

10.  [Spontaneous chromosome aberrations in familial panmyelopathy].

Authors:  T M Schroeder; F Anschütz; A Knopp
Journal:  Humangenetik       Date:  1964
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  9 in total

1.  No abnormalities in the NAD+ ADP-ribosyltransferase (polymerizing) gene of transformed cells from a Fanconi's anemia patient.

Authors:  K Flick; R Schneider; B Auer; M Hirsch-Kauffmann; M Schweiger
Journal:  Hum Genet       Date:  1992-08       Impact factor: 4.132

2.  Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response.

Authors:  M Digweed; S Zakrzewski-Lüdcke; K Sperling
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

3.  Formation of positive supercoiled DNA by a nuclear factor from myeloma cells.

Authors:  P A Lazo
Journal:  Biochem J       Date:  1985-10-01       Impact factor: 3.857

4.  Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain ("zinc fingers").

Authors:  P Kaiser; B Auer; M Schweiger
Journal:  Mol Gen Genet       Date:  1992-03

5.  Further studies on compartmentalisation of DNA-topoisomerase I in Fanconi anemia tissue.

Authors:  E Wunder
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

6.  Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells.

Authors:  H Youssoufian
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

7.  Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.

Authors:  H Herzog; B U Zabel; R Schneider; B Auer; M Hirsch-Kauffmann; M Schweiger
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

8.  The immunosuppressive substance 2-chloro-2-deoxyadenosine modulates lipoprotein metabolism in a murine macrophage cell line (P388 cells).

Authors:  M Lechleitner; B Auer; U Zilian; F Hoppichler; M Schirmer; B Föger; F Geisen; J R Patsch; G Konwalinka
Journal:  Lipids       Date:  1994-09       Impact factor: 1.880

9.  The Fanconi anemia polypeptide FACC is localized to the cytoplasm.

Authors:  T Yamashita; D L Barber; Y Zhu; N Wu; A D D'Andrea
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205
  9 in total

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