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Literature DB >> 6283358

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.

E H Chang, M E Furth, E M Scolnick, D R Lowy.

Abstract

A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation.

Entities: Gene Species

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Year: 1982 PMID： 6283358 DOI： 10.1038/297479a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

155 in total

1. Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

Authors: V Y Hua; W K Wang; P H Duesberg
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

2. An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions.

Authors: H Kamiya; M Suzuki; Y Komatsu; H Miura; K Kikuchi; T Sakaguchi; N Murata; C Masutani; F Hanaoka; E Ohtsuka
Journal: Nucleic Acids Res Date: 1992-09-11 Impact factor: 16.971

3. A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

Authors: N F Lowndes; P Bushel; L Mendelsohn; J Wu; M Y Yen; M Allan
Journal: Mol Cell Biol Date: 1990-09 Impact factor: 4.272

Review 10. Human oncogenes.

Authors: K Willecke; R Schäfer
Journal: Hum Genet Date: 1984 Impact factor: 4.132

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.

1. Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

2. An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions.

3. A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

4. In vitro and in vivo antiproliferative effects of simvastatin, an HMG-CoA reductase inhibitor, on human glioma cells.

Review 5. MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

6. Conformational effects of amino acid substitutions at positions 10, 12, and 13 in the P21 protein.

Review 7. Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

8. Analysis of AP-1 function in cellular transformation pathways.

Review 9. Aberrant function of the Ras signal transduction pathway in human breast cancer.

Review 10. Human oncogenes.