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Literature DB >> 2201911

A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

N F Lowndes¹, P Bushel, L Mendelsohn, J Wu, M Y Yen, M Allan.

Abstract

We have identified a short, highly repetitive element within intron -1 of the human c-Ha-ras gene. This element was found to be transcribed in both orientations and to be homologous to heterogeneous nonpolyadenylated transcripts. The repetitive element blocked transcriptional readthrough from a strong upstream viral promoter but allowed unimpaired readthrough from the c-Has-ras promoter. We suggest that it may serve to prevent excessive transcription into the coding region of the gene under such circumstances as viral insertion.

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Year: 1990 PMID： 2201911 PMCID： PMC361132 DOI： 10.1128/mcb.10.9.4990-4995.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

31 in total

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Authors: D L Bentley; M Groudine
Journal: Nature Date: 1986 Jun 12-18 Impact factor: 49.962

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Authors: D J Capon; E Y Chen; A D Levinson; P H Seeburg; D V Goeddel
Journal: Nature Date: 1983-03-03 Impact factor: 49.962

3. Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.

Authors: E P Reddy
Journal: Science Date: 1983-06-03 Impact factor: 47.728

4. Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.

Authors: D Eick; G W Bornkamm
Journal: Nucleic Acids Res Date: 1986-11-11 Impact factor: 16.971

5. Expression of p21 ras oncoproteins in human cancers.

Authors: T Tanaka; D J Slamon; H Battifora; M J Cline
Journal: Cancer Res Date: 1986-03 Impact factor: 12.701

6. A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene.

Authors: J L Bos; M Verlaan-de Vries; C J Marshall; G H Veeneman; J H van Boom; A J van der Eb
Journal: Nucleic Acids Res Date: 1986-02-11 Impact factor: 16.971

7. A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation.

Authors: D F Gaffney; J McLauchlan; J L Whitton; J B Clements
Journal: Nucleic Acids Res Date: 1985-11-11 Impact factor: 16.971

8. Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis.

Authors: M Linial; N Gunderson; M Groudine
Journal: Science Date: 1985-12-06 Impact factor: 47.728

9. Expression of p21ras in fresh primary and metastatic human colorectal tumors.

Authors: G E Gallick; R Kurzrock; W S Kloetzer; R B Arlinghaus; J U Gutterman
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

10. Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript.

Authors: D Westaway; J Papkoff; C Moscovici; H E Varmus
Journal: EMBO J Date: 1986-02 Impact factor: 11.598

6 in total

Review 1. Genome canalization: the coevolution of transposable and interspersed repetitive elements with single copy DNA.

Authors: R M von Sternberg; G E Novick; G P Gao; R J Herrera
Journal: Genetica Date: 1992 Impact factor: 1.082

2. Presence of Vi-transposon-like elements in the proopiomelanocortin gene A of Xenopus laevis does not affect gene activity.

Authors: P M Deen; E W Roubos; G J Martens
Journal: Mol Gen Genet Date: 1991-12