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Literature DB >> 6255196

Iodination of hepatitis A virus reveals a fourth structural polypeptide.

Abstract

Hepatitis A virus present in the feces of two patients with naturally acquired hepatitis A was purified, radiolabeled with 125I, and analyzed by discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In addition to the three structural polypeptides previously reported, a fourth polypeptide with a molecular weight of 14,000 was detected and shown to be a component of hepatitis A virus by immune precipitation techniques. Intact virions were also shown to sediment at 160S on sucrose gradients. These findings are consistent with hepatitis A virus being an enterovirus within the family Picornaviridae.

Entities: Chemical Disease Species

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Year: 1980 PMID： 6255196 PMCID： PMC288845

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

9 in total

1. The polypeptides of hepatitis A virus.

Authors: A G Coulepis; S A Locarnini; A A Ferris; N I Lehmann; I D Gust
Journal: Intervirology Date: 1978 Impact factor: 1.763

2. Purification of hepatitis A virus from human feces.

Authors: S A Locarnini; A G Coulepis; A A Ferris; N I Lehmann; I D Gust
Journal: Intervirology Date: 1978 Impact factor: 1.763

3. Picornaviridae.

Authors: J L Melnick; V I Agol; H L Bachrach; F Brown; P D Cooper; W Fiers; S Gard; J H Gear; Y Ghendon; L Kasza; M LaPlaca; B Mandel; S McGregor; S B Mohanty; G Plummer; R R Rueckert; F L Schaffer; I Tagaya; D A Tyrrell; M Voroshilova; H A Wenner
Journal: Intervirology Date: 1974 Impact factor: 1.763

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

5. Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis.

Authors: J E Maynard; D Lorenz; D W Bradley; S M Feinstone; D H Krushak; L F Barker; R H Purcell
Journal: Am J Med Sci Date: 1975 Jul-Aug Impact factor: 2.378

6. A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody.

Authors: R H Purcell; D C Wong; Y Moritsugu; J L Dienstag; J A Routenberg; J D Boggs
Journal: J Immunol Date: 1976-02 Impact factor: 5.422

7. A prospective study of acute viral hepatitis with particular reference to hepatitis A.

Authors: S A Locarnini; I D Gust; A A Ferris; A C Stott; M L Wong
Journal: Bull World Health Organ Date: 1976 Impact factor: 9.408

8. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

Authors: S M Feinstone; A Z Kapikian; R H Purceli
Journal: Science Date: 1973-12-07 Impact factor: 47.728

9 in total

1. Primary structure and gene organization of human hepatitis A virus.

Authors: R Najarian; D Caput; W Gee; S J Potter; A Renard; J Merryweather; G Van Nest; D Dina
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

2. Isolation and molecular cloning of a fast-growing strain of human hepatitis A virus from its double-stranded replicative form.

Authors: A Venuti; C Di Russo; N del Grosso; A M Patti; F Ruggeri; P R De Stasio; M G Martiniello; P Pagnotti; A M Degener; M Midulla
Journal: J Virol Date: 1985-11 Impact factor: 5.103

9. Isolation and immunizations with hepatitis A viral structural proteins: induction of antiprotein, antiviral, and neutralizing responses.

Authors: J V Hughes; L W Stanton
Journal: J Virol Date: 1985-08 Impact factor: 5.103

9 in total

Iodination of hepatitis A virus reveals a fourth structural polypeptide.

1. The polypeptides of hepatitis A virus.

2. Purification of hepatitis A virus from human feces.

3. Picornaviridae.

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

5. Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis.

6. A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody.

7. A prospective study of acute viral hepatitis with particular reference to hepatitis A.

8. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

1. Primary structure and gene organization of human hepatitis A virus.

2. Isolation and molecular cloning of a fast-growing strain of human hepatitis A virus from its double-stranded replicative form.

3. Structure of the hepatitis A virion: identification of potential surface-exposed regions.

4. Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site.

5. Evidence that the genome of hepatitis A virus consists of single-stranded RNA.

6. Characterization and classification of virus particles associated with hepatitis A. III. Structural proteins.

7. Topology and immunoreactivity of capsid proteins in hepatitis A virus.

8. Molecular cloning and partial sequencing of hepatitis A viral cDNA.

9. Isolation and immunizations with hepatitis A viral structural proteins: induction of antiprotein, antiviral, and neutralizing responses.