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Literature DB >> 6254034

Solubilization of active opiate receptors.

W F Simonds, G Koski, R A Streaty, L M Hjelmeland, W A Klee.

Abstract

Receptors that reversibly bind opiates and opioid peptides have been solubilized from brain and neuroblastoma-glioma hybrid cell NG108-15 membranes. Active receptors are specifically solubilized with a new type of detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, which is a zwitterionic derivative of cholic acid. The solubilized receptor complexes behave as large molecules with a Stokes radius of 70 A and contain protein as an essential constituent.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 6254034 PMCID： PMC349897 DOI： 10.1073/pnas.77.8.4623

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Morphine receptors as regulators of adenylate cyclase activity.

Authors: S K Sharma; M Nirenberg; W A Klee
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

2. Narcotic receptor sites in morphine-dependent rats.

Authors: W A Klee; R A Streaty
Journal: Nature Date: 1974-03-01 Impact factor: 49.962

Review 3. The molecular organization of membranes.

Authors: S J Singer
Journal: Annu Rev Biochem Date: 1974 Impact factor: 23.643

4. A highly sensitive adenylate cyclase assay.

Authors: Y Salomon; C Londos; M Rodbell
Journal: Anal Biochem Date: 1974-04 Impact factor: 3.365

5. Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.

Authors: L Terenius
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1973

6. Opiate receptor: demonstration in nervous tissue.

Authors: C B Pert; S H Snyder
Journal: Science Date: 1973-03-09 Impact factor: 47.728

7. Opiate receptor binding: effects of enzymatic treatments.

Authors: G W Pasternak; S H Snyder
Journal: Mol Pharmacol Date: 1974-03 Impact factor: 4.436

8. A neuroblastoma times glioma hybrid cell line with morphine receptors.

Authors: W A Klee; M Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1974-09 Impact factor: 11.205

9. Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.

Authors: E J Simon; J M Hiller; I Edelman
Journal: Proc Natl Acad Sci U S A Date: 1973-07 Impact factor: 11.205

10. Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.

Authors: A Goldstein; L I Lowney; B K Pal
Journal: Proc Natl Acad Sci U S A Date: 1971-08 Impact factor: 11.205

35 in total

Solubilization of active opiate receptors.

1. Morphine receptors as regulators of adenylate cyclase activity.

2. Narcotic receptor sites in morphine-dependent rats.

Review 3. The molecular organization of membranes.

4. A highly sensitive adenylate cyclase assay.

5. Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.

6. Opiate receptor: demonstration in nervous tissue.

7. Opiate receptor binding: effects of enzymatic treatments.

8. A neuroblastoma times glioma hybrid cell line with morphine receptors.

9. Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.

10. Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.

1. NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

2. Molecular characterization of the solubilized receptor of somatostatin from rat pancreatic acinar membranes.

3. Characterization of prostate-tissue-directed monoclonal antibody, alpha-Pro 13.

4. Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.

5. Lipids and collagen matrix restrict the hydraulic permeability within the porous compartment of adult cortical bone.

6. Role of membrane lipids in peptide hormone function: binding of enkephalins to micelles.

7. Isolation and purification of a pemphigus vulgaris antigen from human epidermis.

8. Solubilization and characterization of GABAB receptor binding sites from porcine brain synaptic membranes.

9. Characterization of beta-endorphin binding protein (receptor) from rat brain membranes.

10. Characterization of a laminin receptor from human breast carcinoma tissue.