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Literature DB >> 5288759

Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.

Abstract

A METHOD IS DESCRIBED FOR ANALYZING THE ASSOCIATION OF THE OPIATE NARCOTIC LEVORPHANOL WITH BRAIN TISSUE INTO THREE COMPONENTS: nonsaturable, saturable nonspecific, and saturable stereospecific. The method may be of general applicability for the study of the interaction of drugs with body tissues. In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions. The material responsible for the stereospecific binding might be the opiate receptor.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5288759 PMCID： PMC389284 DOI： 10.1073/pnas.68.8.1742

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

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53 in total

1. Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.

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Journal: Pharmacol Rev Date: 2011-07-13 Impact factor: 25.468