Literature DB >> 1054841

Morphine receptors as regulators of adenylate cyclase activity.

S K Sharma, M Nirenberg, W A Klee.   

Abstract

Morphine inhibits adenylate cyclase (EC 4.6.1.1) activity of neuroblastoma times glioma hybrid cells. The inhibition is stereospecific and is reversed by the antagonist, naloxone. The relative affinities of narcotics for the opiate receptor agree well with their effectiveness as inhibitors of adenylate cyclase. Morphine-sensitive and -insensitive cell lines were found, and the degree of sensitivity was shown to be dependent upon the abundance of narcotic receptors. Thus, morphine receptors are functionally coupled to adenylate cyclase. A molecular mechanism for narcotic addiction and tolerance is proposed.

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Year:  1975        PMID： 1054841      PMCID： PMC432359          DOI： 10.1073/pnas.72.2.590

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Stimulation by thyrotropin of horse thyroid plasma membranes adenylate cyclase: evidence of cooperativity.

Authors:  J M Boeynaems; R Pochet; J E Dumont
Journal:  Biochem Biophys Res Commun       Date:  1974-05-20       Impact factor: 3.575

2.  Adenylate cyclase. A new kinetic analysis of the effects of hormones and fluoride ion.

Authors:  C de Haën
Journal:  J Biol Chem       Date:  1974-05-10       Impact factor: 5.157

3.  Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.

Authors:  H O Collier; A C Roy
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

4.  Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system.

Authors:  M Rodbell; M C Lin; Y Salomon
Journal:  J Biol Chem       Date:  1974-01-10       Impact factor: 5.157

Review 5.  Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.

Authors:  H O Collier; A C Roy
Journal:  Prostaglandins       Date:  1974-09-10

6.  Genetic dissection of neural properties using somatic cell hybrids.

Authors:  J Minna; D Glazer; M Nirenberg
Journal:  Nat New Biol       Date:  1972-02-23

7.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

8.  High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells.

Authors:  T Amano; B Hamprecht; W Kemper
Journal:  Exp Cell Res       Date:  1974-04       Impact factor: 3.905

9.  Kinetic evidence for the presence of two prostaglandin receptor sites regulating the activity of intestinal adenylate cyclase sensitive to Escherichia coli enterotoxin.

Authors:  H S Kantor; P Tao; H C Kiefer
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

10.  5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells.

Authors:  C Londos; Y Salomon; M C Lin; J P Harwood; M Schramm; J Wolff; M Rodbell
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205
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  103 in total

1.  Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

Authors:  Sumita Chakrabarti; Nai-Jiang Liu; Alan R Gintzler
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

2.  Quantitation of parvalbumin+ neurons and human immunodeficiency virus type 1 (HIV-1) regulatory gene expression in the HIV-1 transgenic rat: effects of vitamin A deficiency and morphine.

Authors:  Shireen Sultana; Huifen Li; Adam Puche; Odell Jones; Joseph L Bryant; Walter Royal
Journal:  J Neurovirol       Date:  2010-02       Impact factor: 2.643

Review 3.  Evolving paradigms in the treatment of opioid-induced bowel dysfunction.

Authors:  Jakob Lykke Poulsen; Christina Brock; Anne Estrup Olesen; Matias Nilsson; Asbjørn Mohr Drewes
Journal:  Therap Adv Gastroenterol       Date:  2015-11       Impact factor: 4.409

4.  Tolerance and dependence evoked by an endogenous opiate peptide.

Authors:  A Lampert; M Nirenberg; W A Klee
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

5.  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

Authors:  S K Sharma; W A Klee; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

6.  Effects of vitamin A deficiency and opioids on parvalbumin + interneurons in the hippocampus of the HIV-1 transgenic rat.

Authors:  Ming Guo; Joseph Bryant; Shireen Sultana; Odell Jones; Walter Royal
Journal:  Curr HIV Res       Date:  2012-07       Impact factor: 1.581

7.  Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function.

Authors:  J Howl; T Ismail; A J Strain; C J Kirk; D Anderson; M Wheatley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

8.  Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.

Authors:  G Wu; Z H Lu; P Alfinito; R W Ledeen
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

9.  Opioid dependence prevents the action of pertussis toxin in the guinea-pig myenteric plexus.

Authors:  B Lux; R Schulz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

10.  Hyperpolarization of neuroblastoma-glioma hybrid NG108-15 by vanadium ions.

Authors:  D Lichtstein; D Mullikin-Kilpatrick; A J Blume
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205
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