Literature DB >> 6217275

Helper cell-independent cytotoxic clones in man.

S L Wee, L K Chen, G Strassmann, F H Bach.   

Abstract

We report here a class of helper cell-independent cytotoxic T cell (HITc) clones in man that can proliferate in response to antigenic stimulation as well as mediate cytotoxicity. HITc appear to be rare among clones derived from primary in vitro allosensitized culture, but constitute the majority of clones derived from cells sensitized to autologous Epstein-Barr virus-transformed lymphoblastoid cell lines. The implications of the derivation and function of HITc clones are discussed.

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Year:  1982        PMID： 6217275      PMCID： PMC2186881          DOI： 10.1084/jem.156.6.1854

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

Review 1.  Differential function of major histocompatibility complex antigens in T-lymphocyte activation.

Authors:  F H Bach; M L Bach; P M Sondel
Journal:  Nature       Date:  1976-01-29       Impact factor: 49.962

2.  T-cell lines which cooperate in generation of specific cytolytic activity.

Authors:  A L Glasebrook; F W Fitch
Journal:  Nature       Date:  1979-03-08       Impact factor: 49.962

3.  Cell mediated immunity: separation of cells involved in recognitive and destructive phases.

Authors:  F H Bach; M Segall; K S Zier; P M Sondel; B J Alter; M L Bach
Journal:  Science       Date:  1973-04-27       Impact factor: 47.728

4.  Early detection and specificity analysis of human cytolytic T lymphocyte (CTL) colonies generated in soft agarose culture: a potential assay for definition of CTL defined (CD) determinants.

Authors:  S L Wee; S Wu; B J Alter; F H Bach
Journal:  Hum Immunol       Date:  1981-08       Impact factor: 2.850

5.  HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes.

Authors:  M J Sheehy; P M Sondel; M L Bach; R Wank; F H Bach
Journal:  Science       Date:  1975-06-27       Impact factor: 47.728

6.  Stimulation with autologous lymphoblastoid cell lines: lysis of Epstein-Barr virus-positive and -negative cell lines by two phenotypically distinguishable effector cell populations.

Authors:  J M Zarling; M S Dierckins; E A Sevenich; K A Clouse
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

7.  Alternative pathways of T lymphocyte activation.

Authors:  F H Bach; B J Alter
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

8.  Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

9.  Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

Authors:  A L Glasebrook; F W Fitch
Journal:  J Exp Med       Date:  1980-04-01       Impact factor: 14.307

10.  Generation of a lymphocyte growth factor by treatment of human cells with neuraminidase and galactose oxidase.

Authors:  A Novogrodsky; M Suthanthiran; B Saltz; D Newman; A L Rubin; K H Stenzel
Journal:  J Exp Med       Date:  1980-03-01       Impact factor: 14.307
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  7 in total

1.  Spinal fluid lymphocytes responsive to autologous and allogeneic cells in multiple sclerosis and control individuals.

Authors:  G Birnbaum; L Kotilinek; M Schwartz; M Sternad
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

2.  HLA class I specific T lymphocyte clones with dual alloreactive functions.

Authors:  N Flomenberg; C Russo; S Ferrone; B Dupont
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

3.  Recombinant interferon alpha can induce rearrangement of T-cell antigen receptor alpha-chain genes and maturation to cytotoxicity in T-lymphocyte clones in vitro.

Authors:  L K Chen; D Mathieu-Mahul; F H Bach; J Dausset; A Bensussan; M Sasportes
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  Equivalent helper functions of human "naive" and "memory" CD4+ T cells for the generation of alloreactive cytotoxic T lymphocytes.

Authors:  N Yamashita; R Bullington; L T Clement
Journal:  J Clin Immunol       Date:  1990-09       Impact factor: 8.317

5.  Human T-cell hybrids with HLA-restricted proliferative response to Epstein-Barr virus-infected B cells.

Authors:  G Gallagher; W H Stimson
Journal:  Immunology       Date:  1984-12       Impact factor: 7.397

6.  Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation.

Authors:  S Sad; D Kägi; T R Mosmann
Journal:  J Exp Med       Date:  1996-10-01       Impact factor: 14.307

7.  Detection of T cell receptor alpha chain locus rearrangements in human antigen-specific T lymphocyte clones using a DNA probe specific for chromosome region 14q11.

Authors:  D Mathieu-Mahul; L K Chen; C J Larsen; A Bensussan
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
  7 in total

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