Literature DB >> 3486246

Detection of T cell receptor alpha chain locus rearrangements in human antigen-specific T lymphocyte clones using a DNA probe specific for chromosome region 14q11.

D Mathieu-Mahul, L K Chen, C J Larsen, A Bensussan.   

Abstract

Human cloned antigen-specific T lymphocytes were used to characterize DNA rearrangements using a cDNA probe from the T cell receptor (TCR)-alpha chain gene. Rearranged patterns were detected in some T cell clones, confirming that normal mature T cells are rearranged in TCR-alpha locus. Similarly, rearranged DNA patterns were found in T cell clones from the same panel, using a DNA probe (clone K-40, [1]) isolated from chromosome 14 (14q11), where the TCR-alpha locus has been mapped. These results suggest that this genomic DNA clone is located within the TCR-alpha chain locus.

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Year:  1986        PMID： 3486246      PMCID： PMC2188096          DOI： 10.1084/jem.163.5.1308

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  20 in total

1.  Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain.

Authors:  Y Yoshikai; S P Clark; S Taylor; U Sohn; B I Wilson; M D Minden; T W Mak
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

Review 2.  Histocompatibility-linked immune response genes.

Authors:  B Benacerraf; H O McDevitt
Journal:  Science       Date:  1972-01-21       Impact factor: 47.728

3.  Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias.

Authors:  J Erikson; D L Williams; J Finan; P C Nowell; C M Croce
Journal:  Science       Date:  1985-08-23       Impact factor: 47.728

4.  Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor.

Authors:  S C Meuer; O Acuto; R E Hussey; J C Hodgdon; K A Fitzgerald; S F Schlossman; E L Reinherz
Journal:  Nature       Date:  1983-06-30       Impact factor: 49.962

5.  Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.

Authors:  R Lidereau; D Mathieu-Mahul; C Theillet; M Renaud; M Mauchauffé; J Gest; C J Larsen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

6.  H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

Authors:  R M Zinkernagel; P C Doherty
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

7.  Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones.

Authors:  A Bensussan; S C Meuer; S F Schlossman; E L Reinherz
Journal:  J Exp Med       Date:  1984-02-01       Impact factor: 14.307

8.  Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes.

Authors:  G Corradin; J M Chiller
Journal:  J Exp Med       Date:  1979-02-01       Impact factor: 14.307

9.  Helper cell-independent cytotoxic clones in man.

Authors:  S L Wee; L K Chen; G Strassmann; F H Bach
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307

10.  Molecular cloning of a DNA fragment from human chromosome 14(14q11) involved in T-cell malignancies.

Authors:  D Mathieu-Mahul; J F Caubet; A Bernheim; M Mauchauffé; E Palmer; R Berger; C J Larsen
Journal:  EMBO J       Date:  1985-12-16       Impact factor: 11.598
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