Literature DB >> 6215841

Comparison in rats of the anti-inflammatory and gastric irritant effects of etodolac with several clinically effective anti-inflammatory drugs.

R R Martel, J Klicius.   

Abstract

The anti-inflammatory and gastric effects of etodolac were compared in the rat with those of seven clinically established nonsteroidal anti-inflammatory drugs. The anti-inflammatory potency of etodolac was found to lie between that of sulindac and piroxicam. Etodolac was 2.8 times more active than sulindac and 2.2 times less active than piroxicam. Compared to phenylbutazone it was 12.5 times more potent. The irritation produced on the gastric mucosa was less than that of sulindac, although this difference did not reach statistical significance. However, etodolac was significantly (p less than 0.05) less irritant than piroxicam. Of the drugs studied, etodolac showed the highest ratio between the irritant ED50 and the dose which inhibited inflammation by 50%. From these results etodolac is predicted to be a potent anti-inflammatory drug with a high gastric tolerance. Clinical trials appear to confirm these predictions.

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Year:  1982        PMID： 6215841     DOI： 10.1007/bf01965392

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  A sensitive method for the comparative bioassay of nonsteroidal anti-inflammatory compounds in adjuvant-induced primary inflammation in the rat.

Authors:  J Wax; D K Tessman; C V Winder; M D Stephens
Journal:  J Pharmacol Exp Ther       Date:  1975-01       Impact factor: 4.030

2.  A simple precise method for measuring rodent paw volume.

Authors:  J M Hall; C Hallett
Journal:  J Pharm Pharmacol       Date:  1975-08       Impact factor: 3.765

3.  Comparative effects of antiarthritic and other pharmacological agents in the 18-hour arthritis and carrageenan edema tests in rats.

Authors:  R D Sofia; L Danielsen; H B Vassar
Journal:  Pharmacol Res Commun       Date:  1979-02

4.  Investigation of 1,3,4,9-Tetrahydro-1-popylpyrano [3,4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats.

Authors:  R R Martel; J Klicius; F Herr
Journal:  Agents Actions       Date:  1974-12

Review 5.  Antirheumatic drugs: clinical pharmacology and therapeutic use.

Authors:  G L Craig; W W Buchanan
Journal:  Drugs       Date:  1980-12       Impact factor: 9.546

6.  Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.

Authors:  R R Martel; C A Demerson; L G Humber; A H Philipp
Journal:  J Med Chem       Date:  1976-03       Impact factor: 7.446

7.  Effect of ring substitution on the metabolic fate and anti-inflammatory activity of some prodolic acid analogs.

Authors:  W T Robinson; R R Martel; E Ferdinandi; M Kraml
Journal:  J Pharmacol Exp Ther       Date:  1977-12       Impact factor: 4.030

8.  Anti-inflammatory and analgesic properties of etodolic acid in rats.

Authors:  R R Martel; J Klicius
Journal:  Can J Physiol Pharmacol       Date:  1976-06       Impact factor: 2.273

9.  Chemistry and antiinflammatory activities of prodolic-acid and related 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-alkanoic acids. 1.

Authors:  C A Demerson; L G Humber; T A Dobson; R R Martel
Journal:  J Med Chem       Date:  1975-02       Impact factor: 7.446

10.  Comparative efficacy of etodolac and placebo in rheumatoid arthritic patients.

Authors:  G Vetter; M Placchi; L Joubert
Journal:  Int J Clin Pharmacol Ther Toxicol       Date:  1982-05
  10 in total
  14 in total

1.  The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase.

Authors:  D J Schrier; M A Adamchak; A M Boctor; C R Kostlan; D L Flynn; J H Jordan; M E Lesch; G C Okonkwo
Journal:  Agents Actions       Date:  1989-06

2.  Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats.

Authors:  R R Martel; J Klicius; G Metcalf; G A Rona
Journal:  Agents Actions       Date:  1984-10

Review 3.  Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states.

Authors:  J A Balfour; M M Buckley
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

4.  Modulation of extracellular matrix metabolism in rabbit articular chondrocytes and human rheumatoid synovial cells by the non-steroidal anti-inflammatory drug etodolac. II: Glycosaminoglycan synthesis.

Authors:  F Redini; A Mauviel; G Loyau; J P Pujol
Journal:  Agents Actions       Date:  1990-11

5.  Endoscopic evaluation of etodolac and naproxen, and their relative effects on gastric and duodenal prostaglandins.

Authors:  R I Russell
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

6.  The effect of cigarette smoke on gastroduodenal mucosal endogenous prostacyclin level (experimental and clinical observations).

Authors:  G A Balint; V Varró
Journal:  Agents Actions       Date:  1986-11

7.  Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen.

Authors:  R R Martel; J Klicius; G Metcalf
Journal:  Agents Actions       Date:  1984-02

8.  Comparative effects of etodolac, indomethacin, and benoxaprofen on icosanoid biosynthesis.

Authors:  P Sirois; C Saura; H Salari; P Borgeat
Journal:  Inflammation       Date:  1984-12       Impact factor: 4.092

9.  Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.

Authors:  Mahadevappa Hemshekhar; Ram Mohan Thushara; Sadashivaiah Jnaneshwari; Sannaningaiah Devaraja; Kempaiah Kemparaju; Kesturu Subbaiah Girish
Journal:  Eur J Nutr       Date:  2012-12-27       Impact factor: 5.614

10.  Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.

Authors:  R Melarange; C Gentry; M Durie; C O'Connell; P R Blower
Journal:  Dig Dis Sci       Date:  1994-03       Impact factor: 3.199
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