Literature DB >> 6210292

Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.

D Hadjiolov, N Frank, D Mundt, B Spiegelhalder, M Wiessler, D Schmähl.   

Abstract

We have studied the effects of disulfiram (DSF) administration on the metabolism of nitrosodiethylamine (NDEA) in rats during acute and chronic administration. DSF was found to have the following effects during the course of carcinogenesis: (a) marked decrease in the exhalation of 14CO2 derived from 14C-NDEA; (b) reduction of the total levels of DNA and RNA ethylation in the liver. In acute experiments DSF caused an increase in the amount of NDEA in organs and in the urine. We suggest that inhibition of NDEA biotransformation and the subsequent decrease in the total level of DNA ethylation may prevent specific chemical interactions relevant to carcinogenesis.

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Year:  1984        PMID： 6210292     DOI： 10.1007/bf00390458

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  14 in total

1.  ISOLATION CHARACTERISTICS OF RAPIDLY LABELLED RNA FROM NORMAL RAT LIVER.

Authors:  C KIDSON; K S KIRBY; R K RALPH
Journal:  J Mol Biol       Date:  1963-09       Impact factor: 5.469

2.  Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.

Authors:  J V Frei; P D Lawley
Journal:  Chem Biol Interact       Date:  1975-06       Impact factor: 5.192

3.  The inhibition of dimethylnitrosamine carcinogenesis in rat liver by aminoacetonitrile.

Authors:  D Hadjiolov
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

4.  Rapid ion-exchange chromatographic microanalysis of ultraviolet-absorbing materials and its application to nucleosides.

Authors:  M Uziel; C K Koh; W E Cohn
Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

5.  Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.

Authors:  L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1975-04       Impact factor: 13.506

6.  Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet.

Authors:  C C Irving; A J Tice; W M Murphy
Journal:  Cancer Res       Date:  1979-08       Impact factor: 12.701

7.  Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels.

Authors:  A E Pegg
Journal:  J Natl Cancer Inst       Date:  1977-03       Impact factor: 13.506

8.  Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram.

Authors:  D Hadjiolov; N Frank; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-10

9.  Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.

Authors:  N Frank; D Hadjiolov; B Bertram; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

10.  Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.

Authors:  D Schmähl; F W Krüger; M Habs; B Diehl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-03-19
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  2 in total

1.  Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis.

Authors:  D Hadjiolov; N Frank; C Moog; K Spirov
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  Effect of ten thiocompounds on rat liver DNA damage induced by a small dose of N-nitrosodimethylamine.

Authors:  G Brambilla; P Carlo; R Finollo
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153
  2 in total

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