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Literature DB >> 1127713

Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.

Abstract

Disulfiram added to the diet of female CF1 mice inhibited large-bowel neoplasia produced by repeated subcutaneous administrations of dimethylhydrazine (DMH). The mice on a control diet all showed multiple tumors of the large bowel after DMH treatments, whereas there was no evidence of neoplasia in mice given disulfiram.

Entities: Chemical Disease Species

Mesh：

Substances：
Hydrazines
Disulfiram

Year: 1975 PMID： 1127713 DOI： 10.1093/jnci/54.4.1005

Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506

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Cited

16 in total

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Review 2. Cancer chemoprevention.

Authors: A C Griffin
Journal: J Cancer Res Clin Oncol Date: 1980 Impact factor: 4.553

3. Disulfiram deregulates HIF-α subunits and blunts tumor adaptation to hypoxia in hepatoma cells.

Authors: Hye-joon Park; Min-sung Kim; Kumsun Cho; Jang-hyuk Yun; Yong-joon Choi; Chung-hyun Cho
Journal: Acta Pharmacol Sin Date: 2013-07-15 Impact factor: 6.150

4. Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

Authors: J Schuhmacher; H R Scherf; B Bertram; E Frei; H Hauser; M Wiessler
Journal: J Cancer Res Clin Oncol Date: 1985 Impact factor: 4.553

5. Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.

Authors: E S Fiala; C Stathopoulos
Journal: J Cancer Res Clin Oncol Date: 1984 Impact factor: 4.553

6. The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice.

Authors: P R Kerklaan; S Bouter; J A Zijlstra; G R Mohn
Journal: J Cancer Res Clin Oncol Date: 1986 Impact factor: 4.553

Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.

1. The role of natural products in revealing NRF2 function.

Review 2. Cancer chemoprevention.

3. Disulfiram deregulates HIF-α subunits and blunts tumor adaptation to hypoxia in hepatoma cells.

4. Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

5. Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.

6. The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice.

7. Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.

8. Metabolism and pharmacokinetics of S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine in rats.

9. Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.

10. Effects of selenium on chemical carcinogenesis : Comparative effects of antioxidants.