Literature DB >> 145745

Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram.

D Hadjiolov, N Frank, D Schmähl.   

Abstract

Disulfiram (DSF) delayed the appearance of diethylnitrosamine (DEN)-induced strand breaks in liver DNA of rats. The fragmentation of liver DNA produced by DEN was studied 4 and 24 h after administration of the carcinogen on alkaline sucrose gradients. A single dose of 500 mg/kg DSF given 1 h prior to carcinogen treatment delayed for at least 4 h the DEN--induced strand breaks in liver DNA. A single DSF pretreatment, however, did not protect against carcinogen-induced strand breaks when observed 24 h after DEN injection. It is possible that continuous administration of DSF might inhibit the DEN-produced damage of the genetic material.

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Year:  1977        PMID： 145745     DOI： 10.1007/bf00306025

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  7 in total

1.  The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system.

Authors:  J M KISSANE; E ROBINS
Journal:  J Biol Chem       Date:  1958-07       Impact factor: 5.157

2.  Effect of aminoacetonitrile on the metabolism of diethylnitrosamine during liver carcinogenesis.

Authors:  D Mundt; D Hadjiolov
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

3.  A method for measuring DNA damage and repair in the liver in vivo.

Authors:  R Cox; I Damjanov; S E Abanobi; D S Sarma
Journal:  Cancer Res       Date:  1973-09       Impact factor: 12.701

4.  The inhibition of dimethylnitrosamine carcinogenesis in rat liver by aminoacetonitrile.

Authors:  D Hadjiolov
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

5.  Strand breakage in rat liver DNA and its repair following administration of cyclic nitrosamines.

Authors:  B W Stewart; E Farber
Journal:  Cancer Res       Date:  1973-12       Impact factor: 12.701

6.  Inhibition of dimethylnitrosamine-induced strand breaks in liver DNA and liver cell necrosis by diethyldithiocarbamate.

Authors:  S E Abanobi; J A Popp; S K Chang; G W Harrington; P D Lotlikar; D Hadjiolov; M Levitt; S Rajalakshmi; D S Sarma
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506

7.  Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.

Authors:  D Schmähl; F W Krüger; M Habs; B Diehl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-03-19
  7 in total
  5 in total

1.  Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

Authors:  J Schuhmacher; H R Scherf; B Bertram; E Frei; H Hauser; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

2.  Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis.

Authors:  D Hadjiolov; N Frank; C Moog; K Spirov
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

3.  The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate.

Authors:  T S Ying; D S Sarma; E Farber
Journal:  Am J Pathol       Date:  1980-04       Impact factor: 4.307

4.  Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.

Authors:  N Frank; D Hadjiolov; B Bertram; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

5.  Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.

Authors:  D Hadjiolov; N Frank; D Mundt; B Spiegelhalder; M Wiessler; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553
  5 in total

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