Literature DB >> 7462300

Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.

N Frank, D Hadjiolov, B Bertram, M Wiessler.   

Abstract

The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram protects against the alkylating effect of 14C nitrosodiethylamine only for a distinct period of time.

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Year:  1980        PMID： 7462300     DOI： 10.1007/bf00409908

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.

Authors:  J V Frei; P D Lawley
Journal:  Chem Biol Interact       Date:  1975-06       Impact factor: 5.192

Review 2.  Inhibitors of chemical carcinogenesis.

Authors:  L W Wattenberg
Journal:  Adv Cancer Res       Date:  1978       Impact factor: 6.242

3.  Effect of aminoacetonitrile on the metabolism of diethylnitrosamine during liver carcinogenesis.

Authors:  D Mundt; D Hadjiolov
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

4.  The inhibition of dimethylnitrosamine carcinogenesis in rat liver by aminoacetonitrile.

Authors:  D Hadjiolov
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

5.  Rapid ion-exchange chromatographic microanalysis of ultraviolet-absorbing materials and its application to nucleosides.

Authors:  M Uziel; C K Koh; W E Cohn
Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

6.  Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet.

Authors:  C C Irving; A J Tice; W M Murphy
Journal:  Cancer Res       Date:  1979-08       Impact factor: 12.701

7.  Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.

Authors:  R Goth; M F Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

8.  Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram.

Authors:  D Hadjiolov; N Frank; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-10

9.  Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.

Authors:  D Schmähl; F W Krüger; M Habs; B Diehl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-03-19
  9 in total
  4 in total

1.  Glutathione inhibits the alkylation of liver dna by n-nitrosodimethylamine.

Authors:  E Frei; B Bertram; M Wiessler
Journal:  Naturwissenschaften       Date:  1983-01

2.  [Effect of disulfiram on the toxicity and carcinogenicity of N-methyl-n-nitrosobenzylamine in rats (author's transl)].

Authors:  F Schweinsberg; V Bürkle
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

3.  Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

Authors:  J Schuhmacher; H R Scherf; B Bertram; E Frei; H Hauser; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

4.  Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.

Authors:  D Hadjiolov; N Frank; D Mundt; B Spiegelhalder; M Wiessler; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553
  4 in total

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