Literature DB >> 6208553

DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.

T J Ley, Y L Chiang, D Haidaris, N P Anagnou, V L Wilson, W F Anderson.   

Abstract

The human beta-globin gene is expressed--but the human fetal (gamma) and embryonic (epsilon) globin genes are not--in an induced mouse erythroleukemia cell line (M11-X) that contains most of human chromosome 11. A 24-hr exposure of M11-X cells to 5-azacytidine before induction causes "global" DNA hypomethylation but selective activation of the human gamma-globin genes. Genomic DNA is remethylated 2-3 days after exposure to 5-azacytidine, but sequences near the human and mouse globin genes remain hypomethylated, suggesting that the remethylation process is inhibited in these regions.

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Year:  1984        PMID： 6208553      PMCID： PMC391981          DOI： 10.1073/pnas.81.21.6618

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

3.  Human alpha-globin gene expression following chromosomal dependent gene transfer into mouse erythroleukemia cells.

Authors:  A Deisseroth; D Hendrick
Journal:  Cell       Date:  1978-09       Impact factor: 41.582

4.  DNA restriction endonuclease analysis for localization of human beta- and delta-globin genes on chromosome 11.

Authors:  A F Scott; J A Phillips; B R Migeon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

Review 5.  Erythroleukemic differentiation.

Authors:  P A Marks; R A Rifkind
Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

6.  The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites.

Authors:  D A Konkel; S M Tilghman; P Leder
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

7.  Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids.

Authors:  M C Willing; A W Nienhuis; W F Anderson
Journal:  Nature       Date:  1979-02-15       Impact factor: 49.962

8.  Sequence of the human insulin gene.

Authors:  G I Bell; R L Pictet; W J Rutter; B Cordell; E Tischer; H M Goodman
Journal:  Nature       Date:  1980-03-06       Impact factor: 49.962

9.  DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations.

Authors:  C Waalwijk; R A Flavell
Journal:  Nucleic Acids Res       Date:  1978-12       Impact factor: 16.971

10.  Accumulation of alpha- and beta-globin messenger RNAs in mouse erythroleukemia cells.

Authors:  U Nudel; J Salmon; E Fibach; M Terada; R Rifkind; P A Marks; A Bank
Journal:  Cell       Date:  1977-10       Impact factor: 41.582
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  13 in total

1.  MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.

Authors:  Evan P Kransdorf; Shou Zhen Wang; Sheng Zu Zhu; Timothy B Langston; Jeremy W Rupon; Gordon D Ginder
Journal:  Blood       Date:  2006-06-15       Impact factor: 22.113

2.  Analysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease.

Authors:  S R Month; R W Wood; P T Trifillis; P J Orchowski; B Sharon; S K Ballas; S Surrey; E Schwartz
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

Review 3.  Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.

Authors:  Daniel E Bauer; Sophia C Kamran; Stuart H Orkin
Journal:  Blood       Date:  2012-08-17       Impact factor: 22.113

4.  5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.

Authors:  R K Humphries; G Dover; N S Young; J G Moore; S Charache; T Ley; A W Nienhuis
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

5.  X chromosome reactivation in mouse embryonal carcinoma cells.

Authors:  G D Paterno; C N Adra; M W McBurney
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

6.  Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.

Authors:  T J Ley; N L Connolly; S Katamine; M S Cheah; R M Senior; K C Robbins
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272

7.  Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice.

Authors:  Jeremy W Rupon; Shou Zhen Wang; Karin Gaensler; Joyce Lloyd; Gordon D Ginder
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-11       Impact factor: 11.205

8.  Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells.

Authors:  V L Wilson; R A Smith; J Longoria; M A Liotta; C M Harper; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

9.  Analysis of chromatin changes associated with the expression of globin and non-globin genes in cell hybrids between erythroid and other cells.

Authors:  N Affara; J Fleming; P S Goldfarb; E Black; B Thiele; P R Harrison
Journal:  Nucleic Acids Res       Date:  1985-08-12       Impact factor: 16.971

10.  Clonal analysis of the malignant properties of B16 melanoma cells treated with the DNA hypomethylating agent 5-azacytidine.

Authors:  D L Trainer; T Kline; G Hensler; R Greig; G Poste
Journal:  Clin Exp Metastasis       Date:  1988 May-Jun       Impact factor: 5.150
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