Literature DB >> 283312

Selective activation of human beta-but not gamma-globin gene in human fibroblast x mouse erythroleukaemia cell hybrids.

M C Willing, A W Nienhuis, W F Anderson.   

Abstract

The human alpha- and beta-globin genes have been activated in MEL X human fibroblast cell hybrids. However, even though the human gamma- and beta-globin genes are closely linked and were shown in these hybrid clones to be present in approximately equal numbers, no human gamma-globin mRNA was produced. Thus, the human beta- and gamma-globin genes in these cells are differentially regulated apparently by a positive regulatory factor(s) specific for individual globin genes.

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Year:  1979        PMID： 283312     DOI： 10.1038/277534a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  30 in total

1.  Correction of a human beta S-globin gene by gene targeting.

Authors:  E G Shesely; H S Kim; W R Shehee; T Papayannopoulou; O Smithies; B W Popovich
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

Review 2.  Control of globin gene expression during development and erythroid differentiation.

Authors:  George Stamatoyannopoulos
Journal:  Exp Hematol       Date:  2005-03       Impact factor: 3.084

3.  Beta-globin gene promoter generates 5' truncated transcripts in the embryonic/fetal erythroid environment.

Authors:  K Khazaie; F Gounari; M Antoniou; E deBoer; F Grosveld
Journal:  Nucleic Acids Res       Date:  1986-09-25       Impact factor: 16.971

4.  Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells.

Authors:  T H Papayannopoulou; D Lindsley; S Kurachi; K Lewison; T Hemenway; M Melis; N P Anagnou; V Najfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

5.  Trans acting regulation of beta globin gene expression in erythroleukemia (K562) cells.

Authors:  K Young; M Donovan-Peluso; R Cubbon; A Bank
Journal:  Nucleic Acids Res       Date:  1985-07-25       Impact factor: 16.971

6.  Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.

Authors:  R D Cone; A Weber-Benarous; D Baorto; R C Mulligan
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

7.  Activation and repression of a beta-globin gene in cell hybrids is accompanied by a shift in its temporal replication.

Authors:  V Dhar; A I Skoultchi; C L Schildkraut
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

8.  A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch.

Authors:  M Melis; G Demopulos; V Najfeld; J W Zhang; M Brice; T Papayannopoulou; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

9.  Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes.

Authors:  G Zitnik; P Hines; G Stamatoyannopoulos; T Papayannopoulou
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

10.  Epigenetic activation of phenylalanine hydroxylase in mouse erythroleukemia cells by the cytoplast of rat hepatoma cells.

Authors:  T V Gopalakrishnan; W F Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205
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