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Literature DB >> 6243748

Sequence of the human insulin gene.

G I Bell, R L Pictet, W J Rutter, B Cordell, E Tischer, H M Goodman.

Abstract

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.

Entities: Gene Species

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Year: 1980 PMID： 6243748 DOI： 10.1038/284026a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

122 in total

1. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis.

Authors: F Qian; D Hanahan; I L Weissman
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

2. The impact of genetic studies of type 2 diabetes on clinical practice.

Authors: Steven C Elbein
Journal: Curr Diab Rep Date: 2003-04 Impact factor: 4.810

3. Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.

Authors: S R Cordle; J Whelan; E Henderson; H Masuoka; P A Weil; R Stein
Journal: Mol Cell Biol Date: 1991-05 Impact factor: 4.272

4. In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

Authors: K A Metcalfe; G A Hitman; M J Fennessy; M I McCarthy; J Tuomilehto; E Tuomilehto-Wolf
Journal: Diabetologia Date: 1995-10 Impact factor: 10.122

5. Islet amyloid polypeptide (IAPP) is synthesized in the islets of Langerhans. Detection of IAPP polypeptide and IAPP mRNA by combined in situ hybridization and immunohistochemistry in rat pancreas.

Authors: M Denijn; R A De Weger; A D Van Mansfeld; J A van Unnik; C J Lips
Journal: Histochemistry Date: 1992

6. Ontogenesis of thyrotropin-releasing hormone in the human fetal pancreas. A combined radioimmunological and immunocytochemical study.

Authors: P Leduque; S Aratan-Spire; P Czernichow; P M Dubois
Journal: J Clin Invest Date: 1986-10 Impact factor: 14.808

Sequence of the human insulin gene.

1. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis.

2. The impact of genetic studies of type 2 diabetes on clinical practice.

3. Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.

4. In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

5. Islet amyloid polypeptide (IAPP) is synthesized in the islets of Langerhans. Detection of IAPP polypeptide and IAPP mRNA by combined in situ hybridization and immunohistochemistry in rat pancreas.

6. Ontogenesis of thyrotropin-releasing hormone in the human fetal pancreas. A combined radioimmunological and immunocytochemical study.

7. Display of human proinsulin on the Bacillus subtilis spore surface for oral administration.

8. Biosynthesis of rat insulins I and II: evidence for differential expression of the two genes.

9. Isolation and structure of the gene for the progesterone-inducible protein uteroglobin.

10. Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia.