Literature DB >> 6154247

Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries.

A Dembinska-Kiec, W Rücker, P S Schönhöfer.   

Abstract

PGI2 increased cAMP levels in cultured endothelial cells derived from bovine aortas in the presence of isobutylmethylxanthine (IBMX). Stable PGI analogues were more effective, while PGE1 was without effect. In cultured smooth muscle cells from bovine aortas, PGI2, pGE1 and the stable PGI analogues dose-dependently increased cAMP levels in the absence and presence of IBMX. The data confirm the stimulatory effect of PGI2 on cAMP content in bovine coronary artery rings and suggest that the effect is mainly due to the stimulatory action of PGI2 on cAMP in smooth muscle cells.

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Year:  1980        PMID： 6154247     DOI： 10.1007/BF00500304

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Prostacyclin analogs: antiaggregatory potency and enhancement of cAMP levels in human platelet rich plasma.

Authors:  A Dembinska-Kiec; W Rücker; P S Schönhöfer; C Gandolfi
Journal:  Thromb Haemost       Date:  1979-12-21       Impact factor: 5.249

3.  Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries.

Authors:  K Schrör; P Rösen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

4.  Influence of prostaglandin E1 on cyclic 3',5'-AMP levels and glycosaminoglycan secretion of fibroblasts cultured in vitro.

Authors:  H D Peters; K Karzel; D Padberg; P S Schönhöfer; V Dinnendahl
Journal:  Pol J Pharmacol Pharm       Date:  1974 Jan-Apr

5.  PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.

Authors:  A Dembinska-Kiec; W Rücker; P S Schönhöfer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-08       Impact factor: 3.000

6.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962

7.  Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium.

Authors:  S Moncada; A G Herman; E A Higgs; J R Vane
Journal:  Thromb Res       Date:  1977-09       Impact factor: 3.944

8.  Properties of calf endothelial cells in culture.

Authors:  E J Macarak; B V Howard; N A Kefalides
Journal:  Lab Invest       Date:  1977-01       Impact factor: 5.662

9.  A protein binding assay for adenosine 3':5'-cyclic monophosphate.

Authors:  A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205
  9 in total
  8 in total

1.  Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: studies in isolated guinea pig hearts.

Authors:  W H Newman; B F Becker; M Heier; S Nees; E Gerlach
Journal:  Pflugers Arch       Date:  1988-11       Impact factor: 3.657

2.  Prevention of murine cerebral malaria by a stable prostacyclin analog.

Authors:  K Sliwa; H J Grundmann; S Neifer; M F Chaves; G Sahlmüller; E Blitstein-Willinger; U Bienzle; P G Kremsner
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

3.  Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.

Authors:  J E Souness; B K Diocee; W Martin; S A Moodie
Journal:  Biochem J       Date:  1990-02-15       Impact factor: 3.857

4.  Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase.

Authors:  P W Shaul; W B Campbell; M A Farrar; R R Magness
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

5.  Relationship between prostacyclin biosynthesis and cyclic AMP in cultured rabbit mesothelial cells.

Authors:  V J Van de Velde; H Bult; A G Herman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-04       Impact factor: 3.000

6.  Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.

Authors:  P W Shaul; B Kinane; M A Farrar; L M Buja; R R Magness
Journal:  J Clin Invest       Date:  1991-08       Impact factor: 14.808

7.  Effects of prostacyclin (PGI2) and adenosine (ASN) on total and regional blood flow of isolated, collateralized dog hearts.

Authors:  J Scholtholt; H Birringer; V B Fiedler; B Schölkens
Journal:  Basic Res Cardiol       Date:  1981 May-Jun       Impact factor: 17.165

8.  Effects of vasoactive and inflammatory agents on cyclic AMP levels in W138 fibroblasts, endothelial and vascular smooth muscle cells in culture.

Authors:  A Ager; J L Gordon
Journal:  Agents Actions       Date:  1980-12
  8 in total

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