Literature DB >> 91976

PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.

A Dembinska-Kiec, W Rücker, P S Schönhöfer.   

Abstract

Incubation of bovine coronary artery (BCA) rings with isobutylmethylxanthine (IBMX) resulted in a time-dependent increase of cAMP content. This effect was blocked, when the rings were preincubated with indomethacine or 15-hydroperoxy-arachidonic acid for 5 min, indicating that the IBMX-induced increase in cAMP content may depend on endogenous PGI2 formation. PGE2 did not increase the cAMP content in BCA rings. Dipyridamole did not effect cAMP content, when used as a substitute for IBMX. It is suggested that PGI2 stimulates cAMP formation in arterial walls, but that this effect only becomes visible in the presence of a phosphodiesterase inhibitor.

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Year:  1979        PMID： 91976     DOI： 10.1007/BF00499051

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  19 in total

1.  Cyclic nucleotide phosphodiesterase activities of pig coronary arteries.

Authors:  J N Wells; C E Baird; Y J Hardman; J G Wu
Journal:  Biochim Biophys Acta       Date:  1975-04-19

2.  Changes of cyclic-AMP and cycic-AMP phosphodiesterase in the progression and regression of experimental atherosclerosis.

Authors:  F Numano; H Maezawa
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

3.  Role of cyclic nucleotides in control of smooth muscle contraction.

Authors:  J Diamond
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

4.  Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries.

Authors:  K Schrör; P Rösen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

5.  Prostaglandin I2 stimulation of granulosa cell cyclic AMP production.

Authors:  A K Goff; J Zamecnik; M Ali; D T Armstrong
Journal:  Prostaglandins       Date:  1978-05

6.  Cyclic AMP as a mediator of the relaxing action of papaverine, nitroglycerine, diazoxide and hydralazine in intestinal and vascular smooth muscle.

Authors:  R Andersson
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1973

Review 7.  Role of the platelet in atherogenesis.

Authors:  L A Harker; R Ross; J Glomset
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

8.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

9.  Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets.

Authors:  J E Tateson; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-03

10.  Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin.

Authors:  S Moncada; R Korbut
Journal:  Lancet       Date:  1978-06-17       Impact factor: 79.321
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  6 in total

1.  Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: studies in isolated guinea pig hearts.

Authors:  W H Newman; B F Becker; M Heier; S Nees; E Gerlach
Journal:  Pflugers Arch       Date:  1988-11       Impact factor: 3.657

2.  Effects of dipyridamole in vivo on ATP and cAMP content in platelets and arterial walls and on atherosclerotic plaque formation.

Authors:  A Dembinska-Kiec; W Rücker; P S Schönhöfer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-10       Impact factor: 3.000

3.  Methylene blue but not changes in cyclic GMP inhibits resting and bradykinin-stimulated production of prostacyclin by pig aortic endothelial cells.

Authors:  W Martin; K M Drazan; A C Newby
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

4.  Responses of human, monkey and dog coronary arteries in vitro to carbocyclic thromboxane A2 and vasodilators.

Authors:  N Toda
Journal:  Br J Pharmacol       Date:  1984-10       Impact factor: 8.739

5.  Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries.

Authors:  A Dembinska-Kiec; W Rücker; P S Schönhöfer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-02       Impact factor: 3.000

6.  Endothelium-derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells.

Authors:  W Martin; D G White; A H Henderson
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739
  6 in total

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