Literature DB >> 6122891

Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment.

G J Milton-Thompson, N F Lightfoot, Z Ahmet, R H Hunt, J Barnard, P M Bavin, R W Brimblecombe, D W Darkin, P J Moore, N Viney.   

Abstract

Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimetidine treatment. Bacterial counts and nitrite concentrations tended to increase with pH, but N-nitroso-compound concentrations did not. This study provides no evidence that cimetidine treatment may increase the risk of gastric carcinoma by raising N-nitroso-compound concentrations.

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Year:  1982        PMID： 6122891     DOI： 10.1016/s0140-6736(82)92277-2

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  35 in total

Review 1.  Non-immunological defence mechanisms of the gut.

Authors:  S A Sarker; K Gyr
Journal:  Gut       Date:  1992-07       Impact factor: 23.059

2.  Effect of nizatidine 300 mg at night and omeprazole 20 mg in the morning on 24-hour intragastric pH and bacterial overgrowth in patients with acute duodenal ulcer.

Authors:  R J Brummer; R W Stockbrügger
Journal:  Dig Dis Sci       Date:  1996-10       Impact factor: 3.199

3.  Twice-daily cimetidine does not increase gastric bacterial flora.

Authors:  J T Bourne; R A Mountford; R E Barry
Journal:  Postgrad Med J       Date:  1984-07       Impact factor: 2.401

4.  Effects of one year's treatment with ranitidine and of truncal vagotomy on gastric contents.

Authors:  J M Thomas; J J Misiewicz; A R Cook; M J Hill; P L Smith; C L Walters; J K Forster; L E Martin; D F Woodings
Journal:  Gut       Date:  1987-06       Impact factor: 23.059

5.  Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.

Authors:  B K Sharma; I A Santana; E C Wood; R P Walt; M Pereira; P Noone; P L Smith; C L Walters; R E Pounder
Journal:  Br Med J (Clin Res Ed)       Date:  1984-09-22

6.  Duodenal bacterial overgrowth during treatment in outpatients with omeprazole.

Authors:  M Fried; H Siegrist; R Frei; F Froehlich; P Duroux; J Thorens; A Blum; J Bille; J J Gonvers; K Gyr
Journal:  Gut       Date:  1994-01       Impact factor: 23.059

7.  Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds.

Authors:  E Verdu; F Viani; D Armstrong; R Fraser; H H Siegrist; B Pignatelli; J P Idström; C Cederberg; A L Blum; M Fried
Journal:  Gut       Date:  1994-04       Impact factor: 23.059

8.  Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions.

Authors:  C N Hall; J S Kirkham; T C Northfield
Journal:  Gut       Date:  1987-02       Impact factor: 23.059

9.  Relation between gastric histology and gastric juice pH and nitrite and N-nitroso compound concentrations in the stomach after surgery for duodenal ulcer.

Authors:  P C Watt; J M Sloan; J Donaldson; G Campbell; T L Kennedy
Journal:  J Clin Pathol       Date:  1984-05       Impact factor: 3.411

10.  Relation between intragastric bile acid concentration and mucosal abnormality in the stomach after vagotomy and gastroenterostomy for duodenal ulcer.

Authors:  P C Watt; J M Sloan; T L Kennedy
Journal:  J Clin Pathol       Date:  1984-05       Impact factor: 3.411
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