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Literature DB >> 6111196

Binding of [3H]cimetidine to rat brain tissue.

I R Smith, M T Cleverley, C R Ganellin, K M Metters.

Abstract

Binding of [3H]cimetidine to rat brain tissue was investigated, and a saturable binding with dissociation constant 0.22 +/- 0.05 microM found. This binding is inhibited by a range of imidazole-derived histamine H2-receptor antagonists, but not by a number of non-imidazole H2-receptor antagonists. It is concluded that the [3H]cimetidine binding site in rat brain tissue that is labelled in these experiments is not the histamine H2-receptor.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6111196 DOI： 10.1007/bf01968040

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

19 in total

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10. Multiple binding sites of tricyclic antidepressant drugs to mammalian brain receptors.

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9 in total

1. Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain.

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Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1986-08 Impact factor: 3.000

2. CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.

Authors: Lindsay B Hough; Julia W Nalwalk; James G Phillips; Brian Kern; Zhixing Shan; Mark P Wentland; Iwan J P de Esch; Elwin Janssen; Travis Barr; Rebecca Stadel
Journal: Neuropharmacology Date: 2007-01-20 Impact factor: 5.250

3. Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.

Authors: Rebecca Stadel; Amanda B Carpenter; Julia W Nalwalk; Iwan J P de Esch; Elwin Janssen; Lindsay B Hough
Journal: Eur J Pharmacol Date: 2010-02-06 Impact factor: 4.432

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Authors: J C Foreman; D B Norris; T J Rising; S E Webber
Journal: Br J Pharmacol Date: 1985-10 Impact factor: 8.739

5. High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain.

Authors: Rebecca Stadel; Jun Yang; Julia W Nalwalk; James G Phillips; Lindsay B Hough
Journal: Drug Metab Dispos Date: 2007-12-19 Impact factor: 3.922

6. 3H-tiotidine binding to guinea-pig cortical and striatal membranes.

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Journal: Agents Actions Date: 1986-11

7. Histamine H2-binding on guinea pig cerebral cortex.

Authors: G J Sterk; M W van der Schaar; B Rademaker; H van der Goot; H Timmerman
Journal: Agents Actions Date: 1986-04

8. Effects of centrally administered H2 antagonists in the behavioral despair test.

Authors: K A O'Neill; S B Gertner
Journal: Psychopharmacology (Berl) Date: 1986 Impact factor: 4.530

9. Binding of [3H]ICIA 5165, an H2-receptor antagonist to guinea pig gastric mucosa.

Authors: S T Nielsen
Journal: Agents Actions Date: 1986-08

9 in total