Literature DB >> 23536

Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.

J P Green, C L Johnson, H Weinstein, S Maayani.   

Abstract

D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the histamine H2-receptor. Both D-lysergic acid diethylamide and D-2-bromolysergic acid diethylamide show topological congruency with potent H2-antagonists. D-2-Bromolysergic acid diethylamide is 10 times more potent as an H2-antagonist than cimetidine, which has been the most potent H2-antagonist reported, and D-lysergic acid diethylamide is about equipotent to cimetidine. Blockade of H2-receptors could contribute to the behavioral effects of D-2-bromolysergic acid diethylamide and D-lysergic acid diethylamide.

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Year:  1977        PMID： 23536      PMCID： PMC431860          DOI： 10.1073/pnas.74.12.5697

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  50 in total

1.  Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area.

Authors:  M Garbarg; G Barbin; S Bischoff; H Pollard; J C Schwartz
Journal:  Brain Res       Date:  1976-04-23       Impact factor: 3.252

2.  The dopamine receptor: differential binding of d-LSD and related agents to agonist and antagonist states.

Authors:  I Creese; D R Burt; S H Synder
Journal:  Life Sci       Date:  1975-12-01       Impact factor: 5.037

3.  LSD and 2-bromo-LSD: comparison on effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala.

Authors:  G K Aghajanian
Journal:  Neuropharmacology       Date:  1976-09       Impact factor: 5.250

4.  The distribution and metabolism of lysergic acid diethylamide.

Authors:  J AXELROD; R O BRADY; B WITKOP; E V EVARTS
Journal:  Ann N Y Acad Sci       Date:  1957-03-14       Impact factor: 5.691

5.  Prevention of psychological effects of d-lysergic acid diethylamide (LSD 25) by its 2-brom derivative (BOL 148).

Authors:  K H GINZEL; W MAYER-GROSS
Journal:  Nature       Date:  1956-07-28       Impact factor: 49.962

6.  Some chemical and physical properties associated with histamine antagonism.

Authors:  P B MARSHALL
Journal:  Br J Pharmacol Chemother       Date:  1955-09

7.  Electrophysiological analysis of psychotogenic drug action. II. General nature of lysergic acid diethylamide (LSD) action on central synapses.

Authors:  D P PURPURA
Journal:  AMA Arch Neurol Psychiatry       Date:  1956-02

8.  Histamine synthesizing afferents to the hippocampal region.

Authors:  G Barbin; M Garbarg; J C Schwartz; J Storm-Mathisen
Journal:  J Neurochem       Date:  1976-02       Impact factor: 5.372

9.  Proceedings: 3-(4(5)-imidazolyl) propylguanidine (SK&F 91486) - a partial agonist at histamine H2-receptors.

Authors:  M E Parsons; R C Blakemore; G J Durant; C R Ganellin; A C Rasmussen
Journal:  Agents Actions       Date:  1975-12

10.  The interaction of histamine and guanylnucleotides with cardiac adenylate cyclase and its relationship to cardiac contractility.

Authors:  C L Johnson; H Mizoguchi
Journal:  J Pharmacol Exp Ther       Date:  1977-01       Impact factor: 4.030
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  21 in total

1.  Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells.

Authors:  P D Marley; K A Thomson; K Jachno; M J Johnston
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

2.  Classification of drugs according to receptor binding profiles.

Authors:  A Closse; W Frick; A Dravid; G Bolliger; D Hauser; A Sauter; H J Tobler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000

3.  Binding of [3H]cimetidine to rat brain tissue.

Authors:  I R Smith; M T Cleverley; C R Ganellin; K M Metters
Journal:  Agents Actions       Date:  1980-11

4.  Histamine-sensitive adenylate cyclase in the guinea-pig brain.

Authors:  D G Trist
Journal:  Agents Actions       Date:  1982-04

5.  Temporal changes in the calcium-dependence of the histamine H1-receptor-stimulation of cyclic AMP accumulation in guinea-pig cerebral cortex.

Authors:  J Donaldson; A M Brown; S J Hill
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

6.  Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist.

Authors:  D J Minnema; J S Hendry; J A Rosecrans
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

7.  Histamine stimulates renin release from the isolated perfused rat kidney.

Authors:  U Schwertschlag; E Hackenthal
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

8.  Additional data on the function of hypothalamic histamine.

Authors:  Z Huszti
Journal:  Agents Actions       Date:  1981-04

9.  Histamine H1-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parameters.

Authors:  P R Daum; S J Hill; J M Young
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

10.  Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma.

Authors:  J K Khandelwal; L B Hough; A M Morrishow; J P Green
Journal:  Agents Actions       Date:  1982-12
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