Literature DB >> 3825739

3H-tiotidine binding to guinea-pig cortical and striatal membranes.

I R Smith, B K Leigh, M E Mylek.   

Abstract

3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.

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Year:  1986        PMID： 3825739     DOI： 10.1007/bf01966202

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  14 in total

1.  Histamine-sensitive adenylate cyclase in mammalian brain.

Authors:  L R Hegstrand; P D Kanof; P Greengard
Journal:  Nature       Date:  1976-03-11       Impact factor: 49.962

2.  Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

Authors:  J M Palacios; M Garbarg; G Barbin; J C Schwartz
Journal:  Mol Pharmacol       Date:  1978-11       Impact factor: 4.436

3.  Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.

Authors:  J P Green; C L Johnson; H Weinstein; S Maayani
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  3H-cimetidine and the H2-receptor.

Authors:  S E Warrander; D B Norris; R J Rising; T P Wood
Journal:  Life Sci       Date:  1983-09-19       Impact factor: 5.037

5.  Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

Authors:  A DeLean; P J Munson; D Rodbard
Journal:  Am J Physiol       Date:  1978-08

6.  Brain histamine receptors as targets for antidepressant drugs.

Authors:  P D Kanof; P Greengard
Journal:  Nature       Date:  1978-03-23       Impact factor: 49.962

7.  Properties of 3H-cimetidine binding in rat brain membrane fractions.

Authors:  D A Kendall; J W Ferkany; S J Enna
Journal:  Life Sci       Date:  1980-04-21       Impact factor: 5.037

8.  Evidence for neuronal localization of histamine-N-methyltransferase in rat brain.

Authors:  G Sperk; H Hörtnagl; H Reither; O Hornykiewicz
Journal:  J Neurochem       Date:  1981-08       Impact factor: 5.372

9.  Histamine H2-binding studies in the guinea-pig brain.

Authors:  D B Norris; G A Gajtkowski; T J Rising
Journal:  Agents Actions       Date:  1984-04

10.  Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex.

Authors:  G A Gajtkowski; D B Norris; T J Rising; T P Wood
Journal:  Nature       Date:  1983 Jul 7-13       Impact factor: 49.962
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