Literature DB >> 3018291

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.

H J Field, D M Coen.   

Abstract

Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.

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Year:  1986        PMID： 3018291      PMCID： PMC253927     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  34 in total

1.  Isolation of herpes simplex virus clones and drug resistant mutants in microcultures.

Authors:  R J Klein
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

2.  Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

3.  Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity.

Authors:  A A Nash; H J Field; R Quartey-Papafio
Journal:  J Gen Virol       Date:  1980-06       Impact factor: 3.891

4.  The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

Authors:  H J Field; P Wildy
Journal:  J Hyg (Lond)       Date:  1978-10

5.  Resistance of herpes simplex virus to acycloguanosine--genetic and physical analysis.

Authors:  C S Crumpacker; P Chartrand; J H Subak-Sharpe; N M Wilkie
Journal:  Virology       Date:  1980-08       Impact factor: 3.616

6.  Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus.

Authors:  H J Field; G Darby; P Wildy
Journal:  J Gen Virol       Date:  1980-07       Impact factor: 3.891

7.  Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

Authors:  L E Schnipper; C S Crumpacker
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

8.  Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

Authors:  D M Coen; P A Schaffer
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

9.  Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo.

Authors:  H J Field; G Darby
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

10.  Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

Authors:  J S Gibbs; H C Chiou; J D Hall; D W Mount; M J Retondo; S K Weller; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205
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  19 in total

Review 1.  Resistance of herpesviruses to antiviral drugs.

Authors:  P A Chatis; C S Crumpacker
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

Review 2.  Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

3.  Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.

Authors:  Graciela Andrei; Jan Balzarini; Pierre Fiten; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

Review 4.  Antiviral therapy: current concepts and practices.

Authors:  B Bean
Journal:  Clin Microbiol Rev       Date:  1992-04       Impact factor: 26.132

5.  The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.

Authors:  L Huang; K K Ishii; H Zuccola; A M Gehring; C B Hwang; J Hogle; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

Review 6.  "The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.

Authors:  A K Field; K K Biron
Journal:  Clin Microbiol Rev       Date:  1994-01       Impact factor: 26.132

7.  Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene.

Authors:  D C Bloom; J G Stevens
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

8.  Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways.

Authors:  Maria Dulfary Sanchez; Augusto C Ochoa; Timothy P Foster
Journal:  Antiviral Res       Date:  2016-05-15       Impact factor: 5.970

9.  The pathogenesis of wild type and drug resistant mutant strains of bovine herpesvirus-1 (BHV-1) in the natural host.

Authors:  S E Gilliam; A M Thackray; G A Brown; H J Field
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574

10.  Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.

Authors:  C L Talarico; W C Phelps; K K Biron
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103
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