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Literature DB >> 6092929

Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.

Abstract

F8dl is a simian virus 40 early-region deletion mutant that lacks the simian virus 40 DNA sequences between 0.168 and 0.424 map units. Despite this large deletion, cloned F8dl DNA transforms Fisher rat F111 cells and BALB/3T3 clone A31 mouse cells as efficiently as does cloned simian virus 40 wild-type DNA. These results indicate that less than 40% of the large T-antigen-coding sequence is required for efficient transformation.

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Year: 1984 PMID： 6092929 PMCID： PMC368965 DOI： 10.1128/mcb.4.8.1661-1663.1984

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

10 in total

1. Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors: M S Collett; R L Erikson
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

2. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

Authors: C A Reznikoff; D W Brankow; C Heidelberger
Journal: Cancer Res Date: 1973-12 Impact factor: 12.701

6 in total

1. Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding.

Authors: D Michael-Michalovitz; F Yehiely; E Gottlieb; M Oren
Journal: J Virol Date: 1991-08 Impact factor: 5.103

2. The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

Authors: A Srinivasan; K W Peden; J M Pipas
Journal: J Virol Date: 1989-12 Impact factor: 5.103

3. The simian virus 40 sequences between 0.169 and 0.423 map units are not essential to immortalize early-passage rat embryo cells.

Authors: L Sompayrac; K J Danna
Journal: Mol Cell Biol Date: 1985-05 Impact factor: 4.272

4. Overproduction of protein p53 contributes to simian virus 40-mediated transformation.

Authors: D Michalovitz; D Eliyahu; M Oren
Journal: Mol Cell Biol Date: 1986-10 Impact factor: 4.272

5. Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.

Authors: B Bollag; W F Chuke; R J Frisque
Journal: J Virol Date: 1989-02 Impact factor: 5.103

6. JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: identification of regions restricting transformation by JC virus.

Authors: S Haggerty; D L Walker; R J Frisque
Journal: J Virol Date: 1989-05 Impact factor: 5.103

6 in total

Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.

1. Protein kinase activity associated with the avian sarcoma virus src gene product.

2. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

3. Abortive transformation by polyoma virus.

4. A new technique for the assay of infectivity of human adenovirus 5 DNA.

5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

6. A fragment of the SV40 large T-antigen gene transforms.

7. Isolation and characterization of simian virus 40 early region deletion mutants.

8. Stabilization of the 53,000-dalton nonviral tumor antigen is not required for transformation by simian virus 40.

9. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.