Literature DB >> 3025598

Overproduction of protein p53 contributes to simian virus 40-mediated transformation.

D Michalovitz, D Eliyahu, M Oren.   

Abstract

The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.

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Year:  1986        PMID： 3025598      PMCID： PMC367102          DOI： 10.1128/mcb.6.10.3531-3536.1986

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  37 in total

1.  The SV40 A gene product is required for the production of a 54,000 MW cellular tumor antigen.

Authors:  D I Linzer; W Maltzman; A J Levine
Journal:  Virology       Date:  1979-10-30       Impact factor: 3.616

2.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

3.  Monoclonal antibodies specific for simian virus 40 tumor antigens.

Authors:  E Harlow; L V Crawford; D C Pim; N M Williamson
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

4.  SV40 T antigen binds specifically to a cellular 53 K protein in vitro.

Authors:  F McCormick; R Clark; E Harlow; R Tjian
Journal:  Nature       Date:  1981-07-02       Impact factor: 49.962

5.  The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells.

Authors:  W Maltzman; M Oren; A J Levine
Journal:  Virology       Date:  1981-07-15       Impact factor: 3.616

6.  A fragment of the SV40 large T-antigen gene transforms.

Authors:  C E Clayton; D Murphy; M Lovett; P W Rigby
Journal:  Nature       Date:  1982-09-02       Impact factor: 49.962

7.  Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

Authors:  D I Linzer; A J Levine
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

8.  Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells.

Authors:  W W Colby; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

9.  Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells.

Authors:  F McCormick; E Harlow
Journal:  J Virol       Date:  1980-04       Impact factor: 5.103

10.  Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

Authors:  M Oren; W Maltzman; A J Levine
Journal:  Mol Cell Biol       Date:  1981-02       Impact factor: 4.272
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  21 in total

1.  Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype.

Authors:  Li-an Wu; Junsheng Feng; Lynn Wang; Yan-dong Mu; Andrew Baker; Kevin J Donly; Stephen E Harris; Mary MacDougall; Shuo Chen
Journal:  Cell Tissue Res       Date:  2011-01-27       Impact factor: 5.249

2.  Excess wild-type p53 blocks initiation and maintenance of simian virus 40 transformation.

Authors:  K Fukasawa; G Sakoulas; R E Pollack; S Chen
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

3.  Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding.

Authors:  D Michael-Michalovitz; F Yehiely; E Gottlieb; M Oren
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

4.  MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection.

Authors:  W Henning; G Rohaly; T Kolzau; U Knippschild; H Maacke; W Deppert
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

5.  The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

Authors:  A Srinivasan; K W Peden; J M Pipas
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

6.  Oligomerization of oncoprotein p53.

Authors:  S Kraiss; A Quaiser; M Oren; M Montenarh
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

7.  Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

Authors:  D W Meek; W Eckhart
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

8.  Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies.

Authors:  V Gire; D Wynford-Thomas
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

9.  Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

Authors:  P W Hinds; C A Finlay; A B Frey; A J Levine
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

10.  Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.

Authors:  Andrea Hermannstädter; Christine Ziegler; Marion Kühl; Wolfgang Deppert; Genrich V Tolstonog
Journal:  J Virol       Date:  2009-07-22       Impact factor: 5.103
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