Literature DB >> 3017842

Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.

S Youngman, M Sarfarazi, O W Quarrell, P M Conneally, K Gibbons, P S Harper, D J Shaw, R E Tanzi, M R Wallace, J F Gusella.   

Abstract

Close genetic linkage has been shown between the DNA sequence G8 (locus D4S10) and 16 British families with Huntington disease using the HindIII, EcoR1, Nci1, and Pst1 polymorphisms detected by G8, and by combining all the polymorphisms to give a combined haplotype. Two recombinants have been detected in these families giving a maximum lod score of 17.60 at a theta of 0.02. These results confirm the originally reported linkage between the loci and provide evidence against significant multilocus heterogeneity for Huntington disease.

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Year:  1986        PMID： 3017842     DOI： 10.1007/bf00279096

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

2.  Genetic prediction and family structure in Huntington's chorea.

Authors:  P S Harper; M Sarfarazi
Journal:  Br Med J (Clin Res Ed)       Date:  1985-06-29

3.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

4.  Report of the Committee on the Genetic Constitution of Chromosomes 3 and 4.

Authors:  K K Kidd; J Gusella
Journal:  Cytogenet Cell Genet       Date:  1985

5.  A life table for onset of Huntington's chorea.

Authors:  R G Newcombe
Journal:  Ann Hum Genet       Date:  1981-10       Impact factor: 1.670

6.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

7.  Huntington's Chorea in South Wales. A genetic and epidemiological study.

Authors:  D A Walker; P S Harper; C E Wells; A Tyler; K Davies; R G Newcombe
Journal:  Clin Genet       Date:  1981-04       Impact factor: 4.438

8.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

9.  Huntington's disease: two families with differing clinical features show linkage to the G8 probe.

Authors:  S E Folstein; J A Phillips; D A Meyers; G A Chase; M H Abbott; M L Franz; P G Waber; H H Kazazian; P M Conneally; W Hobbs
Journal:  Science       Date:  1985-08-23       Impact factor: 47.728

10.  Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.

Authors:  J F Gusella; R E Tanzi; P I Bader; M C Phelan; R Stevenson; M R Hayden; K J Hofman; A G Faryniarz; K Gibbons
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962
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  13 in total

1.  Predictive testing for Huntington's disease.

Authors:  P S Harper; M J Morris
Journal:  BMJ       Date:  1989-02-18

Review 2.  A multilocus extension of the affected-pedigree-member method of linkage analysis.

Authors:  D E Weeks; K Lange
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

3.  The end in sight for Huntington disease?

Authors:  C Pritchard; D R Cox; R M Myers
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

4.  Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Authors:  I Kanazawa; I Kondo; J E Ikeda; T Ikeda; Y Shizu; M Yoshida; H Narabayashi; S Kuroda; H Tsunoda; E Mizuta
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

5.  Epidemiological and linkage studies on Huntington's disease in Italy.

Authors:  M Frontali; P Malaspina; C Rossi; A G Jacopini; G Vivona; M S Pergola; A Palena; A Novelletto
Journal:  Hum Genet       Date:  1990-07       Impact factor: 4.132

6.  The affected-pedigree-member method of linkage analysis.

Authors:  D E Weeks; K Lange
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

7.  Some developments on the affected-pedigree-member method of linkage analysis.

Authors:  P J Ward
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

8.  Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

Authors:  R G Snell; L P Lazarou; S Youngman; O W Quarrell; J J Wasmuth; D J Shaw; P S Harper
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

Review 9.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

10.  A recombination event that redefines the Huntington disease region.

Authors:  R G Snell; L M Thompson; D A Tagle; T L Holloway; G Barnes; H G Harley; L A Sandkuijl; M E MacDonald; F S Collins; J F Gusella
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025
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