Literature DB >> 3001311

Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.

P S Harper, S Youngman, M A Anderson, M Sarfarazi, O Quarrell, R Tanzi, D Shaw, P Wallace, P M Conneally, J F Gusella.   

Abstract

Analysis of the polymorphism shown by the DNA probe G8 in eight South Wales families with Huntington's disease has confirmed close genetic linkage between this marker and the disorder, the most likely genetic distance being two centimorgans (cM). The closeness of the linkage suggests that G8 may have clinical applications in genetic prediction for this condition.

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Year:  1985        PMID： 3001311      PMCID： PMC1049504          DOI： 10.1136/jmg.22.6.447

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  6 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

3.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

4.  DNA markers for nervous system diseases.

Authors:  J F Gusella; R E Tanzi; M A Anderson; W Hobbs; K Gibbons; R Raschtchian; T C Gilliam; M R Wallace; N S Wexler; P M Conneally
Journal:  Science       Date:  1984-09-21       Impact factor: 47.728

5.  A life table for onset of Huntington's chorea.

Authors:  R G Newcombe
Journal:  Ann Hum Genet       Date:  1981-10       Impact factor: 1.670

6.  A genetic register for Huntington's chorea in South Wales.

Authors:  P S Harper; A Tyler; S Smith; P Jones; R G Newcombe; V McBroom
Journal:  J Med Genet       Date:  1982-08       Impact factor: 6.318
  6 in total
  11 in total

1.  Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Authors:  I Kanazawa; I Kondo; J E Ikeda; T Ikeda; Y Shizu; M Yoshida; H Narabayashi; S Kuroda; H Tsunoda; E Mizuta
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

2.  Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.

Authors:  S Youngman; M Sarfarazi; O W Quarrell; P M Conneally; K Gibbons; P S Harper; D J Shaw; R E Tanzi; M R Wallace; J F Gusella
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132

3.  Ethics of predictive testing for Huntington's chorea: the need for more information.

Authors:  D I Craufurd; R Harris
Journal:  Br Med J (Clin Res Ed)       Date:  1986-07-26

Review 4.  Diagnosis of genetic disease using recombinant DNA.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132

5.  Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

Authors:  R G Snell; L P Lazarou; S Youngman; O W Quarrell; J J Wasmuth; D J Shaw; P S Harper
Journal:  J Med Genet       Date:  1989-11       Impact factor: 6.318

Review 6.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

7.  Absence of close linkage between benign hereditary chorea and the locus D4S10 (probe G8).

Authors:  O W Quarrell; S Youngman; M Sarfarazi; P S Harper
Journal:  J Med Genet       Date:  1988-03       Impact factor: 6.318

Review 8.  Protein truncation as a common denominator of human neurodegenerative foldopathies.

Authors:  Santosh Jadhav; Norbert Zilka; Michal Novak
Journal:  Mol Neurobiol       Date:  2013-03-21       Impact factor: 5.590

9.  Huntington disease in Finland: linkage disequilibrium of chromosome 4 RFLP haplotypes and exclusion of a tight linkage between the disease and D4S43 locus.

Authors:  E Ikonen; J Palo; J Ott; J Gusella; H Somer; L Karila; A Palotie; L Peltonen
Journal:  Am J Hum Genet       Date:  1990-01       Impact factor: 11.025

10.  Molecular genetics of human chromosome 4.

Authors:  J A Gusella; T C Gilliam; M E MacDonald; S V Cheng; R E Tanzi
Journal:  J Med Genet       Date:  1986-06       Impact factor: 6.318
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