Literature DB >> 599413

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ preparation.

K S Pang, M Rowland.   

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Year:  1977        PMID： 599413     DOI： 10.1007/bf01059690

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


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  11 in total

1.  Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation.

Authors:  R W BRAUER; G F LEONG; R F MCELROY; R J HOLLOWAY
Journal:  Am J Physiol       Date:  1956-03

2.  Influence of congestive heart failure on blood vessels of lidocaine and its active monodeethylated metabolite.

Authors:  H Halkin; P Meffin; K L Melmon; M Rowland
Journal:  Clin Pharmacol Ther       Date:  1975-06       Impact factor: 6.875

3.  Clearance concepts in pharmacokinetics.

Authors:  M Rowland; L Z Benet; G G Graham
Journal:  J Pharmacokinet Biopharm       Date:  1973-04

4.  Influence of route of administration on drug availability.

Authors:  M Rowland
Journal:  J Pharm Sci       Date:  1972-01       Impact factor: 3.534

5.  The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.

Authors:  T L Whitsett; P G Dayton; J L McNay
Journal:  J Pharmacol Exp Ther       Date:  1971-04       Impact factor: 4.030

6.  Determination of lidocaine in blood and tissues.

Authors:  N Benowitz; M Rowland
Journal:  Anesthesiology       Date:  1973-12       Impact factor: 7.892

7.  The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.

Authors:  R A Branch; A S Nies; D G Shand
Journal:  Drug Metab Dispos       Date:  1973 Sep-Oct       Impact factor: 3.922

8.  Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

9.  Hepatic clearance of drugs. II. Experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

10.  Effects of route of administration and blood flow on hepatic drug elimination.

Authors:  D G Shand; D M Kornhauser; G R Wilkinson
Journal:  J Pharmacol Exp Ther       Date:  1975-12       Impact factor: 4.030
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  26 in total

1.  Founding figures of pharmacokinetics: tribute to Malcolm Rowland.

Authors:  Leon Aarons; Leslie Z Benet
Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-12       Impact factor: 2.745

2.  Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate.

Authors:  M S Roberts; S Fraser; A Wagner; L McLeod
Journal:  J Pharmacokinet Biopharm       Date:  1990-06

3.  Availability predictions by hepatic elimination models for Michaelis-Menten kinetics.

Authors:  M S Roberts; J D Donaldson; D Jackett
Journal:  J Pharmacokinet Biopharm       Date:  1989-12

4.  Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.

Authors:  James J Beaudoin; Jacqueline Bezençon; Yanguang Cao; Katsuhiko Mizuno; Sharin E Roth; William J Brock; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2018-11-30       Impact factor: 3.922

5.  Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

Authors:  Philip E Empey; Tricia M Miller; Ashley H Philbrick; John A Melick; Patrick M Kochanek; Samuel M Poloyac
Journal:  Crit Care Med       Date:  2012-04       Impact factor: 7.598

6.  A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination.

Authors:  M V St-Pierre; P I Lee; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1992-04

7.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

Review 8.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

9.  Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on evans blue, sucrose, water, and taurocholate.

Authors:  M S Roberts; S Fraser; A Wagner; L McLeod
Journal:  J Pharmacokinet Biopharm       Date:  1990-06

10.  Sequential first-pass elimination of a metabolite derived from a precursor.

Authors:  K S Pang; J R Gillette
Journal:  J Pharmacokinet Biopharm       Date:  1979-06
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