Literature DB >> 599412

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation.

K S Pang, M Rowland.   

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Year:  1977        PMID： 599412     DOI： 10.1007/bf01059689

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


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  22 in total

1.  Liver circulation and function.

Authors:  R W BRAUER
Journal:  Physiol Rev       Date:  1963-01       Impact factor: 37.312

2.  Effect of insulin on potassium transfer in isolated rat liver.

Authors:  G E MORTIMORE
Journal:  Am J Physiol       Date:  1961-06

3.  Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver.

Authors:  S Keiding; S Johansen; K Winkler; K Tonnesen; N Tygstrup
Journal:  Am J Physiol       Date:  1976-05

4.  The theory and applications of the exchange of inert gas at the lungs and tissues.

Authors:  S S KETY
Journal:  Pharmacol Rev       Date:  1951-03       Impact factor: 25.468

5.  Clearance concepts in pharmacokinetics.

Authors:  M Rowland; L Z Benet; G G Graham
Journal:  J Pharmacokinet Biopharm       Date:  1973-04

6.  The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.

Authors:  T L Whitsett; P G Dayton; J L McNay
Journal:  J Pharmacol Exp Ther       Date:  1971-04       Impact factor: 4.030

7.  Application of salivary concentration data to pharmacokinetic studies with antipyrine.

Authors:  P J Meffin; R L Williams; T F Blaschke; M Rowland
Journal:  J Pharm Sci       Date:  1977-01       Impact factor: 3.534

8.  Determination of lidocaine in blood and tissues.

Authors:  N Benowitz; M Rowland
Journal:  Anesthesiology       Date:  1973-12       Impact factor: 7.892

9.  The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.

Authors:  R A Branch; A S Nies; D G Shand
Journal:  Drug Metab Dispos       Date:  1973 Sep-Oct       Impact factor: 3.922

10.  Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12
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  51 in total

1.  Effect of erythrocytes on the hepatic distribution kinetics of antipyrine.

Authors:  Selma Sahin; Malcolm Rowland
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Jan-Mar       Impact factor: 2.441

2.  Founding figures of pharmacokinetics: tribute to Malcolm Rowland.

Authors:  Leon Aarons; Leslie Z Benet
Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-12       Impact factor: 2.745

3.  Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate.

Authors:  M S Roberts; S Fraser; A Wagner; L McLeod
Journal:  J Pharmacokinet Biopharm       Date:  1990-06

4.  Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.

Authors:  James J Beaudoin; Jacqueline Bezençon; Yanguang Cao; Katsuhiko Mizuno; Sharin E Roth; William J Brock; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2018-11-30       Impact factor: 3.922

5.  Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

Authors:  Philip E Empey; Tricia M Miller; Ashley H Philbrick; John A Melick; Patrick M Kochanek; Samuel M Poloyac
Journal:  Crit Care Med       Date:  2012-04       Impact factor: 7.598

6.  A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination.

Authors:  M V St-Pierre; P I Lee; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1992-04

7.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

8.  Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation.

Authors:  M V St-Pierre; D van den Berg; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

Review 9.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

10.  Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on evans blue, sucrose, water, and taurocholate.

Authors:  M S Roberts; S Fraser; A Wagner; L McLeod
Journal:  J Pharmacokinet Biopharm       Date:  1990-06
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