Literature DB >> 5566766

The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.

T L Whitsett, P G Dayton, J L McNay.   

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Year:  1971        PMID： 5566766

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


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  12 in total

1.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

2.  Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique.

Authors:  K S Pang; W F Lee; W F Cherry; V Yuen; J Accaputo; S Fayz; A J Schwab; C A Goresky
Journal:  J Pharmacokinet Biopharm       Date:  1988-12

3.  A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.

Authors:  M S Roberts; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1986-06

4.  Hepatic clearance of local anesthetics in man.

Authors:  G T Tucker; L Wiklund; A Berlin-Wahlen; L E Mather
Journal:  J Pharmacokinet Biopharm       Date:  1977-04

5.  Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

6.  Hepatic clearance of drugs. II. Experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

7.  Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ preparation.

Authors:  K S Pang; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

8.  On the pharmacokinetics of domperidone in animals and man. I. Plasma levels of domperidone in rats and dogs. Age related absorption and passage through the blood brain barrier in rats.

Authors:  J Heykants; A Knaeps; W Meuldermans; M Michiels
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1981       Impact factor: 2.441

9.  Studies on the metabolism of oestrone sulphate. Comparative perfusions of oestrone and oestrone sulphate through isolated rat livers.

Authors:  M Höller; W Grochtmann; M Napp; H Breuer
Journal:  Biochem J       Date:  1977-09-15       Impact factor: 3.857

10.  Determinants of serum antipyrine half-lives in patients with liver disease.

Authors:  R A Branch; C M Herbert; A E Read
Journal:  Gut       Date:  1973-07       Impact factor: 23.059
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