Literature DB >> 599411

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.

K S Pang, M Rowland.   

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Year:  1977        PMID: 599411     DOI: 10.1007/bf01059688

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN: 0090-466X


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  31 in total

1.  Hepatic elimination kinetics: the influence of hepatic blood flow on clearance determination.

Authors:  S Keiding
Journal:  Scand J Clin Lab Invest       Date:  1976-03       Impact factor: 1.713

2.  The effect of the upright posture upon hepatic blood flow in normotensive and hypertensive subjects.

Authors:  J W CULBERTSON; R W WILKINS; F J INGELFINGER; S E BRADLEY
Journal:  J Clin Invest       Date:  1951-03       Impact factor: 14.808

3.  Nonliner tissue disposition: salicylic acid in rat brain.

Authors:  M A Gonzalez; T N Tozer; T T Chang
Journal:  J Pharm Sci       Date:  1975-01       Impact factor: 3.534

4.  Perfusion-limited of plasma drug binding on hepatic drug extraction.

Authors:  D G Shand; R H Cotham; G R Wilkinson
Journal:  Life Sci       Date:  1976-07-01       Impact factor: 5.037

5.  Clearance and biologic half-life as indices of intrinsic hepatic metabolism.

Authors:  D Perrier; M Gibaldi
Journal:  J Pharmacol Exp Ther       Date:  1974-10       Impact factor: 4.030

6.  Capillary-tissue exchange kinetics: diffusional interactions between adjacent capillaries.

Authors:  C A Goresky; H L Goldsmith
Journal:  Adv Exp Med Biol       Date:  1973       Impact factor: 2.622

7.  Absorption kinetics of aspirin in man following oral administration of an aqueous solution.

Authors:  M Rowland; S Riegelman; P A Harris; S D Sholkoff
Journal:  J Pharm Sci       Date:  1972-03       Impact factor: 3.534

8.  Influence of route of administration on drug availability.

Authors:  M Rowland
Journal:  J Pharm Sci       Date:  1972-01       Impact factor: 3.534

9.  The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.

Authors:  T L Whitsett; P G Dayton; J L McNay
Journal:  J Pharmacol Exp Ther       Date:  1971-04       Impact factor: 4.030

10.  The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.

Authors:  R A Branch; A S Nies; D G Shand
Journal:  Drug Metab Dispos       Date:  1973 Sep-Oct       Impact factor: 3.922

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  192 in total

1.  Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model.

Authors:  M S Roberts; Y G Anissimov
Journal:  J Pharmacokinet Biopharm       Date:  1999-08

2.  Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method.

Authors:  A Hisaka; Y Sugiyama
Journal:  J Pharmacokinet Biopharm       Date:  1998-10

3.  A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics.

Authors:  Yuri G Anissimov; Michael S Roberts
Journal:  J Pharmacokinet Pharmacodyn       Date:  2002-04       Impact factor: 2.745

4.  Statistical moments and disposition parameters in a local perfusion system under mammillary nonequilibrium condition.

Authors:  T Kakutani; E Nara; M Hashida
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

5.  Metabolic characterization of a tripeptide human immunodeficiency virus type 1 protease inhibitor, KNI-272, in rat liver microsomes.

Authors:  A Kiriyama; T Nishiura; H Yamaji; K Takada
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

6.  Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution.

Authors:  Brian J Kirby; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2010-08-19       Impact factor: 3.922

7.  The impairment of lignocaine clearance by propranolol--major contribution from enzyme inhibition.

Authors:  N D Bax; G T Tucker; M S Lennard; H F Woods
Journal:  Br J Clin Pharmacol       Date:  1985-05       Impact factor: 4.335

8.  Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach.

Authors:  Cécile Gérard; Jeanick Stocco; Anne Hulin; Benoit Blanchet; Céline Verstuyft; François Durand; Filomena Conti; Christophe Duvoux; Michel Tod
Journal:  AAPS J       Date:  2014-02-14       Impact factor: 4.009

9.  Sequential first-pass elimination of a metabolite derived from a precursor.

Authors:  K S Pang; J R Gillette
Journal:  J Pharmacokinet Biopharm       Date:  1979-06

Review 10.  Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels.

Authors:  Kyoung Ah Min; Xinyuan Zhang; Jing-yu Yu; Gus R Rosania
Journal:  Biopharm Drug Dispos       Date:  2013-12-10       Impact factor: 1.627

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